Aponeocarzinostatin - A superior drug carrier exhibiting unusually high endurance against denaturants

Abstract

The enediyne antitumor antibiotic chromoproteins are very potent in causing DNA damages. During the drug delivery time course, the stability of the carrier protein becomes all important concern. To simulate conceivably offensive environment in biological contexts, such as cell membrane, we studied structural endurance of aponeocarzinostatin against several denaturants by circular dichroism and nuclear magnetic resonance spectroscopy. For comparison, we also examined proteins known to be stable and similar in size to aponeocarzinostatin The results highlight the unusual structural stability of aponeocarzinostatin against chemical denaturants, Suggesting the potential of aponeocarzinostatin as an inherently superior carrier in drug delivery systems. (c) 2006 Elsevier Ltd. All rights reserved.