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標題: An Analyte Derivatization Approach for Improved Electrochemical Detection Amoxicillin
作者: Chiu, M.H.
Chang, J.L.
Zen, J.M.
關鍵字: Amoxicillin;Manganese dioxide;Screen-printed carbon electrode;Sensors;Environmental chemistry;beta-lactam antibiotics;carbon-paste electrode;tandem;mass-spectrometry;liquid-chromatography;spectrophotometric;determination;voltammetric determination;injection-analysis;bovine-milk;ampicillin;plasma
Project: Electroanalysis
期刊/報告no:: Electroanalysis, Volume 21, Issue 14, Page(s) 1562-1567.
Ibis paper introduces an interesting analyte derivatization approach for improved electrochemical detection of amoxicillin (one of the most frequently used P-lactam antibiotics). It is based on the well-known chemical conversion of catechols to o-quinones by MnO(2) that can be subsequently easily determined by electrochemical reduction at inexpensive screen-printed carbon electrodes. The MnO(2) reactor is essential to the proposed amperometric sensor not only to increase the electroactivity but also to achieve the detection selectivity. Under the optimized conditions of applied potential = 0.0 V vs. Ag/AgCl and flow rate 500 mu L/min, the measurement range was over 3 orders of magnitude with a detection limit (S/N= 3) of 17 nM.
ISSN: 1040-0397
DOI: 10.1002/elan.200904604
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