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標題: Determination of codeine in human plasma and drug formulation using a chemically modified electrode
作者: Zen, J.M.
Chang, M.R.
Chung, H.H.
Shih, Y.
關鍵字: codeine;flow injection analysis;human plasma;square-wave voltammetry;chemically modified electrode;performance liquid-chromatography;electrochemical detection;morphine;norcodeine
Project: Electroanalysis
期刊/報告no:: Electroanalysis, Volume 10, Issue 8, Page(s) 536-540.
Bath flow injection methodology and square-wave voltammetry were developed and evaluated for determining codeine in human plasma and pharmaceutical formulations using a Nafion/ruthenium oxide pyrochlore chemically modified electrode. Combining the electrocatalytic function of the ruthenium-oxide pyrochlore with charge-exclusion and the preconcentration features of Nafion perform weil in codeine detection. Compared to a bare glassy carbon electrode. the chemically modified electrode exhibits a shift of the oxidation potential in cathodic direction and a marked enhancement of the current response. A linear calibration plot is obtained over the 0-32 mu M range in 0.05 M HClO4 solution with a detection limit (3 sigma) of 10 nM in the square-wave voltammetric method. While, in flow-injection analysis, a linear calibration plot is obtained over the 0.5-40 mu M range with a detection limit of 0.86 ng. Quantitative analysis was performed by the standard addition method for codeine content in human plasma and a commercially available drug.
ISSN: 1040-0397
Appears in Collections:化學系所

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