Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/34788
DC FieldValueLanguage
dc.contributor.authorZen, J.M.en_US
dc.contributor.author曾志明zh_TW
dc.contributor.authorChen, P.Y.en_US
dc.contributor.authorKumar, A.S.en_US
dc.date2002zh_TW
dc.date.accessioned2014-06-06T07:48:20Z-
dc.date.available2014-06-06T07:48:20Z-
dc.identifier.issn1040-0397zh_TW
dc.identifier.urihttp://hdl.handle.net/11455/34788-
dc.description.abstractAllopurinol is a pharmaceutical drug mainly used for the treatment of chronic gout. It is an antioxidant as well as a powerful inhibitor of xanthine oxidase. Very few electroanalytical assays were reported for allopurinol detection so far. No faradic process of allopurinol was observed by cyclic voltammetry at a glassy carbon electrode. A systematic decrease in current signal of ascorbic acid was observed upon the addition of allopurinol due to the inhibitory action. By taking ascorbic acid as the mobile phase, the above property was utilized to develop a sensitive detection scheme for allopurinol by flow injection analysis. Possible inhibition pathway is derived in terms of radical coupling mechanism. Under optimized conditions, the calibration plot showed a linear range up to 150 muM with a detection limit (S/N = 3) of 0.5 muM (i.e., 1.3 ng in 20 muL sample loop). The precision for 18 successive injection of 0.1 mM allopurinol showed a relative standard deviation of less than 2%. The proposed method is used to detect the amount of allopurinol in a commercially available pharmaceutical drug to show its potential use in real applications.en_US
dc.language.isoen_USzh_TW
dc.relationElectroanalysisen_US
dc.relation.ispartofseriesElectroanalysis, Volume 14, Issue 10, Page(s) 645-649.en_US
dc.relation.urihttp://dx.doi.org/10.1002/1521-4109(200205)14:10<645::aid-elan645>3.0.coen_US
dc.relation.uri2-ken_US
dc.subjectallopurinolen_US
dc.subjectascorbic aciden_US
dc.subjectflow injection analysisen_US
dc.subjectascorbic-aciden_US
dc.subjectoxypurinolen_US
dc.subjectoxidationen_US
dc.titleFlow injection analysis of allopurinol by enzymeless approach at glassy carbon electrodesen_US
dc.typeJournal Articlezh_TW
dc.identifier.doi10.1002/1521-4109(200205)14:10<645::aid-elan645>3.0.co;2-kzh_TW
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeJournal Article-
item.cerifentitytypePublications-
item.fulltextno fulltext-
item.languageiso639-1en_US-
item.grantfulltextnone-
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