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|標題:||Mechanistic studies and sensitive determination of norepinephrine at a nafion/lead-ruthenium oxide pyrochlore chemically modified electrode||作者:||Zen, J.M.
|關鍵字:||norepinephrine;lead-ruthenium oxide pyrochlore;chemically modified;electrode;electrocatalytic oxidation;voltammetric determination;acid;hydrazine;secretion;cells;ruo2;dna||Project:||Electroanalysis||期刊/報告no：:||Electroanalysis, Volume 13, Issue 6, Page(s) 457-464.||摘要:||
Nafion/Lead-ruthenium oxide pyrochlore (Pb2Ru1.75Pb0.25O7-y) chemically modified electrode (NCME) exhibits excellent electrocatalytic response towards the norepinephrine (NE) oxidation reaction. NE oxidation by CV studies show the following main features: i) elechochemical oxidation of NE to o-quinone derivative (Al), ii) intramolecular cyclization of o-quinone derivative to leucodopachrome derivative, iii) further oxidation to dopachrome (A2), and iv) formation of polymeric melanine like products. Controlled product analysis using UV-visible spectroscopy gives evidence of the participation of leucodopachrome derivative (lambda = 425 nm) intermediate. The electrocatalytic oxidation process of Al is mediated by the electrochemically active Ru-VI present in the pyrochlore network. The electrocatalytic reaction follows the Michaelis-Menten type kinetics, similar to an enzymatic mechanism. The determination of NE on the NCME was performed using square-cave voltammetry. A linear calibration plot was obtained over 0-6 muM with a detection limit (3 sigma) of 7.44 nM. The NCR IE showed high stability and no marked interference in the presence of glucose, ascorbic acid, and oxalic acid.
|Appears in Collections:||化學系所|
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