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標題: Determination of codeine in urine and drug formulations using a clay-modified screen-printed carbon electrode
作者: Shih, Y.
Zen, J.M.
Yang, H.H.
關鍵字: codeine;clay;screen-printed carbon electrode;drug;urine;performance liquid-chromatography;gas-chromatography;paste electrodes;morphine;plasma;chemiluminescence;blood
Project: Journal of Pharmaceutical and Biomedical Analysis
期刊/報告no:: Journal of Pharmaceutical and Biomedical Analysis, Volume 29, Issue 5, Page(s) 827-833.
Both flow-injection analysis and square-wave stripping voltammetry were evaluated for the determination of codeine in pharmaceutical formulations using a nontronite clay-modified screen-printed carbon electrode. Compared with a bare screen-printed carbon electrode, the nontronite clay-modified screen-printed carbon electrode exhibited a marked enhancement of the current response of codeine. A linear calibration plot was obtained over the 2.5-45 muM range (correlation coefficient = 0.999) in pH 6.0 phosphate buffer solution with a detection limit of 20 nM (S/N= 3) by square-wave voltammetry (SWV). While, in flow-injection analysis, the linearity was over 5-120 ng range with a detection limit of 1 ng in 20 mul loop. The nontronite clay-modified screen-printed carbon electrode can be either disposable or reused since the renewal gave a good reproducible surface. Quantitative analysis was performed by the standard addition method for codeine content in both urine and commercially available drugs. (C) 2002 Elsevier Science B.V. All rights reserved.
ISSN: 0731-7085
DOI: 10.1016/s0731-7085(02)00179-6
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