Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/34864
DC FieldValueLanguage
dc.contributor.authorShih, Y.en_US
dc.contributor.author曾志明zh_TW
dc.contributor.authorWu, K.L.en_US
dc.contributor.authorSue, J.W.en_US
dc.contributor.authorKumar, A.S.en_US
dc.contributor.authorZen, J.M.en_US
dc.date2008zh_TW
dc.date.accessioned2014-06-06T07:48:28Z-
dc.date.available2014-06-06T07:48:28Z-
dc.identifier.issn0731-7085zh_TW
dc.identifier.urihttp://hdl.handle.net/11455/34864-
dc.description.abstractTranexamic acid (TA) is an important reagent in cosmetic skin-whitening formulation and a drug for the inhibition of plasminogen to plasmin in blood. Since there is no chromophore in tranexamic acid molecule to enable direct analysis by UV-visible absorption spectrophotometry, derivatization is thus required by excluding use of UV or fluorescence detection. We report here a relatively simple electrochemical TA detection method by using a barrel plating nickel electrode. Chromatographic separation was performed on a Hamilton PRP-X100 anion-exchange column (150mm x 4.1 mm i.d., 10 mu m particle size) with a (85:15, v/v) mixture of 0.1 mol 1(-1) NaOH and acetonitrile as mobile phase and pumped at a flow rate of 0.9 ml min(-1). By detecting at +0.55 V vs. Ag/AgCl, the calibration plot was linear in the concentration window of 3-1000 ppm with regression coefficient and detection limit (S/N=3) of 0.9993 and 0.13 ppm (0.84 mu mol 1(-1)), respectively. Successive injections (n= 10) of 50 ppm tranexamic acid showed a R.S.D. value of only 0.3% indicating good reproducibility of the proposed system. The method was successfuliy applied to the analysis of the content of tranexamic acid in cosmetic products and proved to be suitable for rapid and reliable quality control. (C) 2008 Elsevier B.V. All rights reserved.en_US
dc.language.isoen_USzh_TW
dc.relationJournal of Pharmaceutical and Biomedical Analysisen_US
dc.relation.ispartofseriesJournal of Pharmaceutical and Biomedical Analysis, Volume 48, Issue 5, Page(s) 1446-1450.en_US
dc.relation.urihttp://dx.doi.org/10.1016/jjpba.2008.09.019en_US
dc.subjectTranexamic aciden_US
dc.subjectDisposableen_US
dc.subjectBarrel plating nickel electrodeen_US
dc.subjectCosmeticsen_US
dc.subjectepsilon-aminocaproic aciden_US
dc.subjectflow-injection analysisen_US
dc.subjectcardiopulmonaryen_US
dc.subjectbypassen_US
dc.subjectalkaline-solutionen_US
dc.subjectderivatizationen_US
dc.subjectoxidationen_US
dc.subjectplasmaen_US
dc.subjectformulationsen_US
dc.subjecthydroxideen_US
dc.subjectchromiumen_US
dc.titleDetermination of tranexamic acid in cosmetic products by high-performance liquid chromatography coupled with barrel plating nickel electrodeen_US
dc.typeJournal Articlezh_TW
dc.identifier.doi10.1016/jjpba.2008.09.019zh_TW
item.languageiso639-1en_US-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.openairetypeJournal Article-
item.fulltextno fulltext-
item.grantfulltextnone-
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