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標題: Determination of theophylline in tea and drug formulation using a Nafion (R)/lead-ruthenium oxide pyrochlore chemically modified electrode
作者: Zen, J.M.
Yu, T.Y.
Shih, Y.
關鍵字: theophylline;tea;drug formulation;chemically-modified electrode;performance liquid-chromatography;voltammetric determination;human;plasma;caffeine;metabolites;immunoassay;oxidation;urine
Project: Talanta
期刊/報告no:: Talanta, Volume 50, Issue 3, Page(s) 635-640.
Square-wave voltammetry was used for the determination of trace amounts of theophylline in tea and drug formulation at a Nafion(R)/lead-ruthenium oxide pyrochlore chemically modified electrode. This chemically modified electrode exhibits a marked enhancement of the current response compared to a bare glassy carbon electrode. The calibration graph for the determination of theophylline was linear up to 100 mu M in 0.1 M, pH 3 phosphate solution with a detection limit (S/N = 3) of 0.1 mu M. The results of 15 successive repetitive measurement-regeneration cycles showed a relative standard deviation of 1.3% for 10 mu M theophylline indicating that the electrode renewal gives a good reproducible surface. Quantitative analysis was performed by the standard addition method for the theophylline content in commercially available tea and drug. (C) 1999 Elsevier Science B.V. All rights reserved.
ISSN: 0039-9140
DOI: 10.1016/s0039-9140(99)00160-5
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