Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/35111
標題: Multifunctional doxorubicin/superparamagnetic iron oxide-encapsulated Pluronic F127 micelles used for chemotherapy/magnetic resonance imaging
作者: Lai, J.R.
賴秉杉
Chang, Y.W.
Yen, H.C.
Yuan, N.Y.
Liao, M.Y.
Hsu, C.Y.
Tsai, J.L.
Lai, P.S.
關鍵字: polymeric micelles;drug-delivery;magnetic nanoparticles;multidrug-resistance;p-glycoproteins;behavior;tissues;systems;agents;size
Project: Journal of Applied Physics
期刊/報告no:: Journal of Applied Physics, Volume 107, Issue 9.
摘要: 
Polymeric micelles are frequently used to transport and deliver drugs throughout the body because they protect against degradation. Research on functional polymeric micelles for biomedical applications has generally shown that micelles have beneficial properties, such as specific functionality, enhanced specific tumor targeting, and stabilized nanostructures. The particular aim of this study was to synthesize and characterize multifunctional polymeric micelles for use in controlled drug delivery systems and biomedical imaging. In this study, a theranostic agent, doxorubicin/superparamagnetic iron oxide (SPIO)-encapsulated Pluronic F127 (F127) micelles, was developed for dual chemotherapy/magnetic resonance imaging (MRI) purposes, and the structure and composition of the micellar SPIO were characterized by transmission electron microscopy and magnetic measurements. Our results revealed that the micellar SPIO with a diameter of around 100 nm led to a significant advantage in terms of T2 relaxation as compared with a commercial SPIO contrast agent (Resovist (R)) without cell toxicity. After doxorubicin encapsulation, a dose-dependent darkening of MR images was observed and HeLa cells were killed by this theranostic micelle. These findings demonstrate that F127 micelles containing chemotherapeutic agents and SPIO could be used as a multifunctional nanocarrier for cancer treatment and imaging. (c) 2010 American Institute of Physics. [doi:10.1063/1.3357344]
URI: http://hdl.handle.net/11455/35111
ISSN: 0021-8979
DOI: 10.1063/1.3357344
Appears in Collections:化學系所

Show full item record
 

Google ScholarTM

Check

Altmetric

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.