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標題: Enhanced photodynamic cancer treatment by supramolecular nanocarriers charged with dendrimer phthalocyanine
作者: Nishiyama, N.
Nakagishi, Y.
Morimoto, Y.
Lai, P.S.
Miyazaki, K.
Urano, K.
Horie, S.
Kumagai, M.
Fukushima, S.
Cheng, Y.
Jang, W.D.
Kikuchi, M.
Kataoka, K.
關鍵字: Photodynamic therapy;Phthalocyanine;Dendrimer;Polymeric micelle;polyion complex micelles;polymeric micelles;photochemical;internalization;block-copolymers;drug-delivery;gene delivery;therapy;photosensitizer;porphyrins;dna
Project: Journal of Controlled Release
期刊/報告no:: Journal of Controlled Release, Volume 133, Issue 3, Page(s) 245-251.
Photodynamic therapy (PDT) is a promising method for the localized treatment of solid tumors. In order to enhance the efficacy of PDT, we have recently developed a novel class of photosensitizer formulation, i.e., the dendrimer phthalocyanine (DPc)-encapsulated polymeric micelle (DPc/m). The DPc/m induced efficient and unprecedentedly rapid cell death accompanied by characteristic morphological changes such as blebbing of cell membranes, when the cells were photoirradiated using a low power halogen lamp or a high power diode laser. The fluorescent microscopic observation using organelle-specific dyes demonstrated that DPc/m might accumulate in the endo-/lysosomes; however, upon photoirradiation, DPc/m might be promptly released into the cytoplasm and photodamage the mitochondria, which may account for the enhanced photocytotoxicity of DPc/m. This study also demonstrated that DPc/m showed significantly higher in vivo PDT efficacy than clinically used Photofrin (R) (polyhematoporphyrin esters, PHE) in mice bearing human lung adenocarcinoma A549 cells. Furthermore, the DPc/m-treated mice did not show skin phototoxiciy, which was apparently observed for the PHE-treated mice, under the tested conditions. These results strongly suggest the usefulness of DPc/m in clinical PDT. (C) 2008 Elsevier B.V. All rights reserved.
ISSN: 0168-3659
DOI: 10.1016/j.jconrel.2008.10.010
Appears in Collections:化學系所

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