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標題: Cytotoxic Lignan Esters from Cinnamomum osmophloeum
作者: Chen, T.H.
Huang, Y.H.
Lin, J.J.
Liau, B.C.
Wang, S.Y.
Wu, Y.C.
Jong, T.T.
關鍵字: Cinnamomum osmophloeum;Lauraceae;9,9'-di-O-feruloyl(+)-5,5'-dimethox;secoisolariciresinol;( 7' S,8' R8R)-lyoniresinol;I-9-O(E)-feruloyl;ester;(7' S,8' R,8R)-lyoniresinol;nol-9,9'-di-O-(E)-feruloyl ester;leaf essential oils;constituents;glycosides;heartwood;bark
Project: Planta Medica
期刊/報告no:: Planta Medica, Volume 76, Issue 6, Page(s) 613-619.
! The bark and roots of Cinnamomum osmophloeum are widely used in Taiwan as spice substitutes for C. cassia. We have isolated three novel lignan esters, one dibenzylbutane-type ligan ester [9,9'di- O-feruloyl-(+)-5,5'-dimethoxy secoisolariciresinol (3)] and two cyclolignan esters [(7' S, 8' R, 8R) -lyoniresinol-9-O-(E)-feruloyl ester (5) and (7' S, 8' R, 8R)-lyoniresinol-9,9'-di-O-(E) -feruloyl ester (6)], and several known lignans from the heartwood and roots of C. osmophloeum. We identified these compounds using 1D and 2D NMR spectroscopy and mass spectrometry. Cytotoxicity assays of these novel lignan esters revealed that compound 6 has strong activities against human liver cancer (HepG2 and Hep3B) and oral cancer (Ca9-22) cells, with IC(50) values of 7.87, 4.31, and 2.51 mu g/mL, respectively.
ISSN: 0032-0943
DOI: 10.1055/s-0029-1240634
Appears in Collections:化學系所

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