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標題: Tetracycline Immobilization as Hydroquinone Derivative at Dissolved Oxygen Reduction Potential on Multiwalled Carbon Nanotube
作者: Kumar, Annamalai Senthil
Sornambikai, Sundaram
Venkatesan, Shanmuganathan
Chang, Jen-Lin
Zen, Jyh-Myng
Project: Journal of The Electrochemical Society, Volume159, Issue 11, page(s) G137-G145.
Upon continuous potential cycling of multiwalled carbon nanotube modified electrode (GCE/MWCNT) with Tetracycline antibiotic
(Tet) at −0.5 to 0.4 V vs Ag/AgCl in pH 7 phosphate buffer solution, the Tet drug gets selectively immobilized as Tet-hydroquinone
derivative (Tet-HQ) on the GCE/MWCNT (GCE/Tet-HQ@MWCNT) and showed a specific surface confined redox peak at E1/2
=−0.24 ± 0.02 V vs Ag/AgCl. Control potential cycling experiment with o-cresol resulted to similar electrochemical characteristic
too. But with p-cresol, no such surface confined redox peak was noticed. Dissolved oxygen reduction to hydrogen peroxide (as an
intermediate species) at −0.45 V vs Ag/AgCl and its chemical oxidation of the surface bound Tet@MWCNT to Tet-HQ@MWCNT
is proposed as a plausible mechanism. Separate ring-disk screen-printed carbon electrode assembly, where MWCNT and a H2O2
detection catalyst (nano-MnO2) modified on the ring and disk respectively, coupled with flow injection analysis showed specific
current signals for oxygen reduction reaction at −0.45 V vs Ag/AgCl on the disk and subsequent H2O2 oxidation on ring at 0.8 V
vs Ag/AgCl. The surface confined redox system showed highly selective electrocatalytic reduction signal to hydrogen peroxide at
∼0.22 V vs Ag/AgCl without any interference from the ascorbic acid, uric acid, cysteine and nitrite.
ISSN: 0013-4651
DOI: 10.1149/2.061211jes
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