Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/36267
標題: 探討類風溼性關節炎病人之維生素B6狀態及代謝
Vitamin B6 status and metabolism in rheumatoid arthritis
作者: 張馨月
Chang, Hsin-Yueh
關鍵字: 磷酸比哆醛(比哆胺、比哆醇)去磷酸酶比哆醛 (比哆胺、比哆醇)激酶磷酸比哆醇(比哆胺)氧化酶;Rheumatoid arthritis;pyridoxal (pyridoxamine, pyridoxine) phosphate phosphatase (PDXP);pyridoxal (pyridoxamine, pyridoxine) kinase (PDXK);pyridoxine (pyridoxamine) phosphate oxidase (PNPO)
出版社: 生物科技學研究所
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摘要: 
類風濕性關節炎(Rheumatoid arthritis,RA)是一種慢性自體免疫疾病。已知病患體內前發炎細胞激素均顯著升高。幾十年來多位學者報導,類風濕性關節炎患者其有數種營養素有異常的現象,特別是血中維生素B6濃度缺乏和功能受損,但是實際的機制仍然不明。已知磷酸比哆醛(比哆胺、比哆醇)去磷酸酶、比哆醛 (比哆胺、比哆醇)激酶、磷酸比哆醇(比哆胺)氧化酶這三種酵素在維生素B6代謝扮演重要的角色。本研究利用臨床人體及動物模式探討類風濕性關節炎病患體內維生素B6代謝異常的機制。我們提出之假說為發炎反應或抗類風濕關節炎用藥可能會透過調控維生素B6代謝基因進而影響病患維生素B6的代謝、平衡及功能。去氫羥化腎上腺皮質素會影響實驗動物維生素B6之代謝,增加動物血漿中維生素B6的濃度。去氫羥化腎上腺皮質素或許可供用於治療或預防由於體內維生素B6缺乏所引起的疾病。此外長期使用非類固醇抗發炎藥物可能會影響類風濕性關節炎病患血漿中維生素B6濃度;並影響動物肝臟、腎臟及紅血球中維生素B6濃度。

Rheumatoid arthritis (RA) has been related with low vitamin B6 status and impaired vitamin B6 function. Three enzymes are involved in the metabolism of vitamin B6 in different tissues. These enzymes are pyridoxal (pyridoxamine, pyridoxine) phosphate phosphatase (PDXP), pyridoxal (pyridoxamine, pyridoxine) kinase (PDXK) and pyridoxine (pyridoxamine) phosphate oxidase (PNPO). There is the possibility that inadequate vitamin B6 levels in RA patients might be result from abnormal vitamin B6 metabolism. The purpose of this study is to examine these enzymes expression in vitamin B6 metabolism and disclose the relationships between these enzymes and vitamin B6 levels in circulating and tissues. In human study, we investigated the plasma and erythrocyte B6 levels in RA patients and controls. Hepatic PDXP gene expressions and hepatic PDXK enzyme activity in animals were affected by prednisolone treatment. In addition, plasma B6 levels were affected in mice by long-term prednisolone treatment. Furthermore, prolonged nonsteroidal antiinflammatory drugs (NSAIDs) treatment attenuated hepatic, kidney and erythrocyte B6 levels in animals. Moreover, it should be concerned about long-term NSAIDs use because their adverse effect on attenuating vitamin B6 status.
URI: http://hdl.handle.net/11455/36267
其他識別: U0005-0108201113442300
Appears in Collections:生物科技學研究所

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