Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/3668
標題: 利用陽離子型界面活性劑與PAAc-g-mPEG接枝高分子形成奈米複合微粒及其結構探討
Structural characterization of nanoparticles from supramolecular assembling of poly(acrylic acid) -graft-poly(ethylene glycol) and cationic surfactants
作者: 蔡佩玲
Tasi, Pei-Ling
關鍵字: polyelectrolyte-surfactant complexes;帶電高分子-界面活性劑之複合微粒;micelles;vesicles;微胞;液胞
出版社: 化學工程學系所
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摘要: 
中文摘要
本研究利用單一及一對疏水碳鏈之陽離子型界面活性劑Dodecyltrimethylammonium bromide (DTAB)、didodecyldimethyl- ammonium bromide (DDAB)分別與陰離子型之接枝高分子以靜電交互作用力相結合。根據螢光(fluorescence technique)、動態光散射(dynamic light scattering, DLS)、界面電位(Zeta potential)分析,顯示DDAB於極低濃度下即能與高分子形成之穩定複合微粒,其疏水程度明顯高於DTAB與高分子所形成之複合微粒,且經由粒子表面負電大幅地降低,說明DDAB能有效地與高分子主鏈之AAc結合,形成較為緻密之複合微粒。
實驗中以氫核-核磁共振光譜儀(1H-NMR)、廣角度X光繞射(wide-angle X-ray diffraction, WAXD)以及穿透式電子顯微鏡(transmission electronic microscopy, TEM)證實DTAB與接枝高分子結合能形成核-殼(core-shell)結構之高分子微胞,核心部分是由DTAB分子之長碳鏈所組成,殼層部分由親水PEG鏈段所構成以穩定粒子;此外,DTAB分子無法提供足夠之親疏水比例,導致高分子微胞結構較為鬆散。當DDAB與接枝高分子結合後會形成單一粒徑分布、且結構穩定的高分子液胞結構,疏水區域由DDAB之一對碳氫鏈以雙層層狀排列結構所組成,親水PEG鏈段位於疏水區域內外兩側以提高粒子穩定性,實驗亦證實其內部水相能成功地包覆親水性之螢光物質FITC-dextran。

SUMMARY
In this study, the formation mechanism and structural characterization of nanoparticles from complexes between the negatively charged poly(acrylic acid)-graft-monomethoxy poly(ethylene glycol), PAAc-g-mPEG, and single- and double-tail cationic surfactants were investigated thoroughly. Dodecyltrimethylammonium bromide (DTAB) and didodecyldimethylammonium bromide (DDAB) were used as the surfactant components. The results of fluorescence, dynamic light scattering and Zeta-potential experiments illustrate that at low surfactant concentration, compared to the complexes of PAAc-g-mPEG and DTAB, the complexes from PAAc-g-mPEG and DDAB are capable of forming more stable and compact nonoparticles. Furthermore, from the combined results of 1H-NMR and wide-angle X-ray diffraction (WXRD), it is verified that the PAAc-g-mPEG/DTAB complexes undergoes self-assembling into micelle-like aggregates with hydrophobic cores from neutralized anionic AAc residues of the copolymer and cationic DTAB and hydrophilic shells from mPEG segments. Interestingly, distinct from micelle-like aggregates formed by PAAc-g-mPEG/DTAB complexes, the vesicle-like nanoparticles from the PAAc-g-mPEG/DDAB complexes exhibit closed and hydrophobic bilayer regions constructed from neutralized AAc units of the copolymer and DDAB. These bilayer regions are surrounded by hydrophilic mPEG segments. In addition, the vesicle-like nanoparticles can encapsulate the water-soluble fluorescein isothiocyanate, FITC-dextrans into their interior aqueous compartments, which display potential applications in drug delivery.
URI: http://hdl.handle.net/11455/3668
其他識別: U0005-0808200810525100
Appears in Collections:化學工程學系所

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