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標題: 以二維數學模型模擬多邊形細胞內被動傳輸與結合機制之關係
A Mathematical Two-Dimension Model Accounting for Binding Mechanisms Effect on Passive diffusion within Polygon Cells
作者: 鍾允廷
關鍵字: apparent diffusion coefficient;表觀擴散係數
出版社: 化學工程學系所
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Intracellular transport of biomolecules within cell plays an important role to maintain normal cellular function. Nerve cells are widely distributed over our bodies, when neuron receives stimulation, it releases chemical mediators, and muscles or glands make proper responses to maintain human homeostasis. Therefore, understanding of intracellular transport mechanisms provides a potential answer for curing diseases, and the corresponding drug applications. This work develops a two dimensional mathematical model describing intracellular passive diffusion in nerve cell and assumes several different binding mechanisms. Furthermore, we analyzed quantitatively the factors that affect intracellular biomolecules diffusion, and then fitted the experimental data by regulating binding factors. The purpose of this work is to determine apparent diffusion coefficients, which relate to the mobility of biomolecules in living cells.
其他識別: U0005-1412200900202600
Appears in Collections:化學工程學系所

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