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標題: Novel Nanohybrids of Silver Particles on Clay Platelets for Inhibiting Silver-Resistant Bacteria
作者: Su, Hong-Lin
Lin, Siou-Hong
Wei, Jiun-Chiou
Pao, I-Chuan
Chiao, Shu-Her
Huang, Chieh-Chen
Lin, Shinn-Zong
Lin, Jiang-Jen
關鍵字: nanoscale silicate platelets;silver nanoparticles;nanohybrid;bacteria,;silver resistant bacteria
Project: Plos One, Volume 6, Issue 6, Page(s) e21125.
We develop a novel nanohybrid showing a strong antibacterial activity on all of the tested pathogens, including methicillin-resistant Staphylococcus auerus and silver-resistant E. coli. The nanohybrid consists of silver nanoparticles (AgNPs) supported on 1 nm-thick silicate platelets (NSPs). The AgNP/NSP nanohybrid enables to encapsulate bacteria and triggers death signals from the cell membrane. The geographic shape of the NSPs concentrates AgNPs but impedes their penetration into attached cells, mitigating the detrimental effect of silver ion deposition in applied tissues. Moreover, the tightly tethered AgNPs on NSP surface achieve a stronger biocidal effect than silver nitrate, but bypassing Ag+ mechanism, on silver-resistant bacteria. This nanohybrid presents an effective and safe antimicrobial agent in a new perspective.
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0021125
Appears in Collections:生命科學系所

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