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標題: Curcumin reduces pulmonary tumorigenesis in vascular endothelial growth factor (VEGF)-overexpressing transgenic mice
作者: Tung, Yu-Tang
Chen, Hsiao-Ling
Lai, Cheng-Wei
Shen, Chih-Jie
Lai, Yi-Wen
Chen, Chuan-Mu
關鍵字: Curcumin;Pulmonary cancer;Transgenic mice;Turmeric;VEGF
Project: Molecular Nutrition & Food Research, Volume 55, Issue 7, Page(s) 1036-1043.
Scope: We investigated the inhibition of pulmonary tumor formation through treatment with curcumin in transgenic mice. Methods and results: In this study, a strain of transgenic mice carrying human vascular endothelial growth factor A(165) (hVEGF-A(165)) gene to induce pulmonary tumor was used as an in vivo cancer therapy model. We found that curcumin significantly reduced hVEGF-A(165) overexpression to normal, specifically in Clara cells of the lungs of transgenic mice, and suppressed the formation of tumors. In addition, we demonstrated a relationship between curcumin treatment and the expression of VEGF, EGFR, ERK2, and Cyclin A at the transcriptional and translational levels. We also noticed a reduction of Cyclin A and Cyclin B after curcumin treatment that had an effect on the cell cycle. Curcumin-induced inhibition of Cyclin A and Cyclin B likely results in decreased progression through S and G2/M phases. These results demonstrated that the expression of proteins involved in the S to M phase transition in transgenic mice is suppressed by curcumin. Conclusion: A Data suggest that a blockade of the cell cycle may be a critical mechanism for the observed effects on vasculogenesis and angiogenesis following treatment with curcumin.
ISSN: 1613-4125
DOI: 10.1002/mnfr.201000654
Appears in Collections:生命科學系所

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