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標題: The distinct effects of a butanol fraction of Bidens pilosa plant extract on the development of Th1-mediated diabetes and Th2-mediated airway inflammation in mice
作者: Chang, C.L.T.
Kuo, H.K.
Chang, S.L.
Chiang, Y.M.
Lee, T.H.
Wu, W.M.
Shyur, L.F.
Yang, W.C.
關鍵字: airway inflammation;Bidens;diabetes;helper T cells (Th);cell-deficient mice;t-cells;pulmonary eosinophilia;immunoglobulin-e;murine model;nod mice;hyperresponsiveness;mouse;lymphocytes;prevention
Project: Journal of Biomedical Science
期刊/報告no:: Journal of Biomedical Science, Volume 12, Issue 1, Page(s) 79-89.
Bidens pilosa is claimed to be useful for immune or anti-inflammatory disorders; however, little scientific evidence has been published concerning its function. In this paper., immune disease mouse models were used to study the function of a butanol fraction of B. pilosa. We demonstrated treatment with the butanol fraction of B. pilosa ameliorated Th1 cell-mediated autoimmune diabetes in nonobese diabetic (NOD) mice but caused deterioration of Th2 cell-mediated airway inflammation induced by ovalbumin (OVA) in BALB/c mice. We next showed that Th2 cytokines (IL-4 and/or IL-5) increased but Th1 cytokine (IFN-gamma) decreased following injections with the butanol fraction of B. pilosa in both mouse strains. Accordingly, Th2 cytokine-regulated IgE production in mouse serum increased following treatment with this fraction. Finally, we found that the butanol fraction of B. pilosa inhibited Th1 cell differentiation but promoted Th2 cell differentiation. Taken together, the butanol fraction of B. pilosa has a dichotomous effect on helper T cell-mediated immune disorders, plausibly via modulation of T cell differentiation.
ISSN: 1021-7770
DOI: 10.1007/s11373-004-8172.x
Appears in Collections:生命科學系所

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