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|標題:||Hypoxia-induced mobilization of stored triglycerides in the euryoxic goby Gillichthys mirabilis||作者:||Gracey, A.Y.
|關鍵字:||hypoxia;fish;triglyceride;microarray;transcriptome;oxygen;leptin;inducible factor-1;lipid-metabolism;gene-expression;transcriptional;responses;thermal-acclimation;apolipoprotein-e;adipose-tissue;heat-stress;obese gene;fish||Project:||Journal of Experimental Biology||期刊/報告no：:||Journal of Experimental Biology, Volume 214, Issue 18, Page(s) 3005-3012.||摘要:||
Environmental hypoxia is a common challenge that many aquatic organisms experience in their habitat. Responding to hypoxia requires metabolic reprogramming so that energy-demanding processes are regulated to match available energy reserves. In this study we explored the transcriptional control of metabolic reorganization in the liver of a hypoxia-tolerant burrow-dwelling goby, Gillichthys mirabilis. Gene expression data revealed that pathways associated with triglyceride hydrolysis were upregulated by hypoxia whereas pathways associated with triglyceride synthesis were downregulated. This finding was supported by tissue histology, which showed that the size of hepatic lipid droplets declined visibly during exposure to hypoxia. Proton nuclear magnetic resonance analysis confirmed the mobilization of hepatic triglycerides, which declined 2.7-fold after 5 days of hypoxia. The enzyme, adipose triglyceride lipase, was implicated in the mobilization of triglycerides because its expression increased at the level of both transcript and protein. This observation raises questions regarding the regulation of fat metabolism during hypoxia and the role played by the hypoxia-responsive gene leptin.
|Appears in Collections:||生命科學系所|
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