Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/3783
標題: 以二維數值模型模擬細胞的擴散及調整空間立體障礙效應與結合機制
A Two-Dimensional Mathematical Model Simulating Intracellular Diffusion Quantifies Contributions of Steric Hindrance and Binding Effect
作者: 郭哲庭
Kuo, Che-Ting
關鍵字: steric hindrance;立體空間障礙;cell;binding effect;viscosity;細胞;結合效應;黏度
出版社: 化學工程學系所
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摘要: 
由於細胞之間的訊息傳遞對生物體很重要,當訊息傳遞發生問題,生物將會發生疾病。所以分子在細胞內的擴散變得很重要,之前有文獻已將結合效應獨立量化。本研究致力於二維空間障礙因子將表觀擴散係數中獨立出來。觀察胞器的大小和位置與擴散速度的關係。從研究的結果中了解空間障礙在擴散程序中所扮演的角色並且也成功的將空間障礙從表觀擴散係數中獨立出來。接著本研究調控空間障礙效應與結合機制效應擬合實驗的數據。

Intracellular mass transport plays as critical role in biological function, a variety of genetic diseases are related to the mal function of intracellular transport. Previous research on quantification of cytoplasmic diffusion coefficient has isolated the binding effect as one of the factor in determination of apparent diffusion coefficient. This research further isolated steric hindrance from factor such a viscosity and binding .Contribution of retarder from diffusion obstacle such as cytoskeleton and organelles are calculated and quantified. Results of the mathematical model are compared with experimental data from literature and satisfactory agreements are obtained.
URI: http://hdl.handle.net/11455/3783
其他識別: U0005-2904200900042500
Appears in Collections:化學工程學系所

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