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|標題:||Equilibrium protein folding-unfolding process involving multiple intermediates||作者:||Hung, H.C.
|關鍵字:||placental alkaline-phosphatase;photinus-pyralis luciferase;stability;ultracentrifugation;disease;states||Project:||Bulletin of Mathematical Biology||期刊/報告no：:||Bulletin of Mathematical Biology, Volume 65, Issue 4, Page(s) 553-570.||摘要:||
Mathematical models for the protein folding-unfolding process involving multiple intermediates have been derived. Computer fitting of the experimental data to this model generates various thermodynamic parameters for the folding-unfolding process. In this way, the complex folding-unfolding process of the multi-domain proteins can be analysed in a quantitative way. The application of the folding-unfolding model involving seven stages in human placental alkaline phosphatase is described. (C) 2003 Society for Mathematical Biology. Published by Elsevier Science Ltd. All rights reserved.
|Appears in Collections:||生命科學系所|
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