Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/38111
標題: Equilibrium protein folding-unfolding process involving multiple intermediates
作者: Hung, H.C.
洪慧芝
Chen, Y.H.
Liu, G.Y.
Lee, H.J.
Chang, G.G.
關鍵字: placental alkaline-phosphatase;photinus-pyralis luciferase;stability;ultracentrifugation;disease;states
Project: Bulletin of Mathematical Biology
期刊/報告no:: Bulletin of Mathematical Biology, Volume 65, Issue 4, Page(s) 553-570.
摘要: 
Mathematical models for the protein folding-unfolding process involving multiple intermediates have been derived. Computer fitting of the experimental data to this model generates various thermodynamic parameters for the folding-unfolding process. In this way, the complex folding-unfolding process of the multi-domain proteins can be analysed in a quantitative way. The application of the folding-unfolding model involving seven stages in human placental alkaline phosphatase is described. (C) 2003 Society for Mathematical Biology. Published by Elsevier Science Ltd. All rights reserved.
URI: http://hdl.handle.net/11455/38111
ISSN: 0092-8240
DOI: 10.1016/s0092-8240(03)00024-7
Appears in Collections:生命科學系所

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