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標題: Hydroxydibenzoylmethane induces apoptosis through repressing ornithine decarboxylase in human promyelocytic leukemia HL-60 cells
作者: Wang, M.F.
Liao, Y.F.
Hung, Y.C.
Lin, C.L.
Hour, T.C.
Lue, K.H.
Hung, H.C.
Liu, G.Y.
Project: Experimental and Molecular Medicine
期刊/報告no:: Experimental and Molecular Medicine, Volume 43, Issue 4, Page(s) 189-196.
Ornithine decarboxylase (ODC) is the rate-limiting enzyme in polyamine biosynthesis and a target for chemoprevention. Hydroxydibenzoylmethane (HDB), a derivative of dibenzoylmethane of licorice, is a promising chemopreventive agent. In this paper, we investigated whether HDB would inhibit the ODC pathway to enhance apoptosis in human promyelocytic leukemia HL-60 cells. We found ODC enzyme activity was reduced during HDB treatment. Overexpression of ODC in HL-60 parental cells could reduce HDB-induced apoptosis, which leads to loss of mitochondrial membrane potential (Delta psi(m)), through lessening intracellular ROS. Furthermore, ODC overexpression protected cytochrome c release and the activation of caspase-3 following HDB treatment. The results demonstrated HDB-induced apoptosis was through a mechanism of down-regulation of ODC and occurred along a ROS-dependent mitochondria-mediated pathway.
ISSN: 1226-3613
DOI: 10.3858/emm.2011.43.4.023
Appears in Collections:生命科學系所

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