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|標題:||Psoriasis Independently Associated With Hyperleptinemia Contributing to Metabolic Syndrome||作者:||Chen, Y.J.
|關鍵字:||myocardial-infarction;leptin;obesity;smoking;disease;adiponectin;population;risk;axis||Project:||Archives of Dermatology||期刊/報告no：:||Archives of Dermatology, Volume 144, Issue 12, Page(s) 1571-1575.||摘要:||
Objective: To evaluate the role of leptin, a 16-kDa adipocyte-derived hormone, in the development of metabolic dysregulation of psoriasis. Design: Case-control study. Setting: Referral centers. Patients: Seventy-seven patients with psoriasis and 81 age- and sex-matched control subjects were included in the study. Intervention: Enzyme-linked immunoassay of serum samples from study subjects. Main Outcome Measures: Serum leptin levels and proportions of comorbidities ( including hypertension, diabetes mellitus, metabolic syndrome, hypertriglyceridemia, and reducedhigh-density lipoprotein cholesterol concentrations) in cases vs controls were compared using chi(2) and Mann-Whitney tests. The clinical significance of leptin in psoriasis was analyzed using logistic regression models. Results: Significantly more obesity ( odds ratio [ OR], 2.67) and hypertension (2.17) (P=. 04 for both) were observed in subjects with psoriasis. High serum leptin levels (>= 7397.43 pg/mL) were found in female subjects (OR, 6.05; P <. 001) and in subjects with obesity (3.45; P=.01), hypertension (2.19; P=. 04), metabolic syndrome (3.58; P=. 008), and psoriasis (2.25; P=. 02). On multivariate analysis, psoriasis ( OR, 4.57; P=. 009) was significantly associated with hyperleptinemia independent of female sex (26.36; P <. 001), metabolic syndrome (4.37; P=. 04), and obesity (2.83; P=. 12). Finally, patients with psoriasis who had hyperleptinemia tended to be female ( P <. 001) and manifested obesity ( P=. 002) and metabolic syndrome ( P=. 003). Conclusions: Hyperleptinemia is associated with psoriasis independent of female sex and other conventional cardiovascular risk factors such as obesity and metabolic syndrome. Hyperleptinemia in psoriasis may contribute to metabolic syndrome.
|Appears in Collections:||生命科學系所|
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