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標題: Porcine lactoferrin as feedstuff additive elevates avian immunity and potentiates vaccination
作者: Hung, C.M.
Wu, S.C.
Yen, C.C.
Lin, M.F.
Lai, Y.W.
Tung, Y.T.
Chen, H.L.
Chen, C.M.
關鍵字: Porcine lactoferrin;Lymphocyte proliferation;Serum antibody titer;Cytokine;Infectious bursal disease (IBD);Vaccination;infectious bursal disease;transgenic mice;pichia-pastoris;methylotrophic yeast;milk lactoferrin;cells;expression;challenge;protects;piglets
Project: Biometals
期刊/報告no:: Biometals, Volume 23, Issue 3, Page(s) 579-587.
In this study, recombinant porcine lactoferrin (PLF) was used as feedstuff additive to investigate the effects of peripheral lymphocyte proliferation and serum antibody titers in chickens vaccinated against the infectious bursal disease (IBD) virus. Treatment groups were fed three doses of PLF powder in their diet (0.5, 1.0, and 2.0% w/w), and the IBD vaccine was administrated at 1 and 3 weeks of age. At 8, 12, and 16 weeks after vaccination, serum IBD antibody titers were measured via the micro-method and T cell proliferation rates were evaluated. The results revealed that a high dose of PLF led to significant increases in serum IgA, IgG and IBD-specific antibody titers (P < 0.05). PLF administration, at either low or high doses, enhanced the expression of IFN-gamma and IL-12 in chicken T lymphocytes. These results suggest that PLF enhances cell-mediated immunity and augment the ability of IBD vaccination to strengthen subsequent anti-viral responses.
ISSN: 0966-0844
DOI: 10.1007/s10534-010-9321-5
Appears in Collections:生命科學系所

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