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標題: Effect of Helicobacter pylori infection on intragastric acidity in patients with reflux esophagitis
作者: 陳全木
Tsai, S.H.
Chen, C.M.
Chang, C.S.
Chen, G.H.
關鍵字: Helicobacter pylori;reflux esophagitis;intragastric acidity;esophageal motility;gastroesophageal-reflux;endoscopic assessment;atrophic gastritis;duodenal-ulcer;serum gastrin;disease;sphincter;secretion;manometry;age
Project: Journal of Gastroenterology
期刊/報告no:: Journal of Gastroenterology, Volume 39, Issue 9, Page(s) 821-826.
Background The effect of Helicobacter pylori infection on intragastric acidity in patients with reflux esophagitis was investigated. Methods. Esophageal motility and 24-h intragastric acidity were assessed in endoscopy-proven reflux esophagitis patients with (n = 50) and without (n = 50) H. pylori infection. Results. Most of the patients had a mild degree of esophagitis. There was no difference in the age, sex, or body mass index (BMI) between patients with and without H. pylori infection. The 24-h intragastric pH monitoring showed less acidity in patients with H. pylori infection than in those without H. pylori infection (median pH, 1.6 +/- 0.3 vs 1.4 +/- 0.1, with vs without H. pylori infection; P < 0.01). No difference in the patterns of esophageal motility dysfunction was noted between these two groups of patients. Conclusions. Patients with reflux esophagitis and H. pylori infection had less intragastric acidity than those without H. pylori infection. However, the extent of acid suppression was insufficient to protect the esophagus from acid injury. In addition, the degree of esophageal motility dysfunction was similar in both groups. Therefore, H. pylori infection may play no role in the pathogenesis of reflux esophagitis.
ISSN: 0944-1174
DOI: 10.1007/s00535-004-1396-8
Appears in Collections:生命科學系所

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