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標題: Clinical and epidemiological implications of swine hepatitis E virus infection
作者: Wu, J.C.
Chen, C.M.
Chiang, T.Y.
Sheen, I.J.
Chen, J.Y.
Tsai, W.H.
Huang, Y.H.
Lee, S.D.
關鍵字: phylogenetic analysis;polymerase;chain reaction;swine hepatitis E;virus;viral hepatitis;non-b hepatitis;non-a;phylogenetic analysis;molecular-cloning;epidemic;sequence;seroreactivity;antibody;outbreak;mexico
Project: Journal of Medical Virology
期刊/報告no:: Journal of Medical Virology, Volume 60, Issue 2, Page(s) 166-171.
In nonendemic areas, most patients with acute hepatitis E were infected through traveling to endemic areas. However, some patients did not have a history of foreign travel before infection. Furthermore, high seroprevalence rates of antibody to hepatitis E virus (anti-HEV) were found in the general adult population in some countries without any recorded outbreak of hepatitis E. The significance of anti-HEV assay in these subjects remains obscure. To study if swine might be a source of HEV infection, HEV was tested in sera of 235 pigs in Taiwan, and from 5 patients with acute HEV infection who either denied or did not provide any foreign travel history. Three (1.3%) pigs had detectable swine HEV RNA. The swine and human HEV strains from Taiwan formed a monophyletic group, distinct from three previously reported groups: the United States human and swine HEV strains, the Mexico strain, and the largest group composed of the Asian and the African strains. The identity of nucleotide sequences was 84-95% between swine and human HEV strains in Taiwan, and 72-79% between Taiwan strains and those from different areas. The predicted amino acid sequence of a Taiwan swine HEV strain within the peptide 3-2 used in commercial anti-HEV assay showed a high identity (91-94%) with those of other human and swine HEV strains. Swine may be a reservoir of HEV and subclinical swine HEV infection may occur. Cross-reactivity of current anti-HEV assay may account for the high prevalence rate of anti-HEV in the general population in nonendemic areas. J. Mad. Virol. 60:166-171, 2000. (C) 2000 Wiley-Liss, Inc.
ISSN: 0146-6615
Appears in Collections:生命科學系所

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