Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/38261
DC FieldValueLanguage
dc.contributor.authorWu, J.C.en_US
dc.contributor.author陳全木zh_TW
dc.contributor.authorChen, C.M.en_US
dc.contributor.authorChiang, T.Y.en_US
dc.contributor.authorSheen, I.J.en_US
dc.contributor.authorChen, J.Y.en_US
dc.contributor.authorTsai, W.H.en_US
dc.contributor.authorHuang, Y.H.en_US
dc.contributor.authorLee, S.D.en_US
dc.date2000zh_TW
dc.date.accessioned2014-06-06T08:00:39Z-
dc.date.available2014-06-06T08:00:39Z-
dc.identifier.issn0146-6615zh_TW
dc.identifier.urihttp://hdl.handle.net/11455/38261-
dc.description.abstractIn nonendemic areas, most patients with acute hepatitis E were infected through traveling to endemic areas. However, some patients did not have a history of foreign travel before infection. Furthermore, high seroprevalence rates of antibody to hepatitis E virus (anti-HEV) were found in the general adult population in some countries without any recorded outbreak of hepatitis E. The significance of anti-HEV assay in these subjects remains obscure. To study if swine might be a source of HEV infection, HEV was tested in sera of 235 pigs in Taiwan, and from 5 patients with acute HEV infection who either denied or did not provide any foreign travel history. Three (1.3%) pigs had detectable swine HEV RNA. The swine and human HEV strains from Taiwan formed a monophyletic group, distinct from three previously reported groups: the United States human and swine HEV strains, the Mexico strain, and the largest group composed of the Asian and the African strains. The identity of nucleotide sequences was 84-95% between swine and human HEV strains in Taiwan, and 72-79% between Taiwan strains and those from different areas. The predicted amino acid sequence of a Taiwan swine HEV strain within the peptide 3-2 used in commercial anti-HEV assay showed a high identity (91-94%) with those of other human and swine HEV strains. Swine may be a reservoir of HEV and subclinical swine HEV infection may occur. Cross-reactivity of current anti-HEV assay may account for the high prevalence rate of anti-HEV in the general population in nonendemic areas. J. Mad. Virol. 60:166-171, 2000. (C) 2000 Wiley-Liss, Inc.en_US
dc.language.isoen_USzh_TW
dc.relationJournal of Medical Virologyen_US
dc.relation.ispartofseriesJournal of Medical Virology, Volume 60, Issue 2, Page(s) 166-171.en_US
dc.relation.uri2-8en_US
dc.relation.urihttp://dx.doi.org/10.1002/(sici)1096-9071(200002)60:2<166::aid-jmv10>3.0.coen_US
dc.subjectphylogenetic analysisen_US
dc.subjectpolymeraseen_US
dc.subjectchain reactionen_US
dc.subjectswine hepatitis Een_US
dc.subjectvirusen_US
dc.subjectviral hepatitisen_US
dc.subjectnon-b hepatitisen_US
dc.subjectnon-aen_US
dc.subjectphylogenetic analysisen_US
dc.subjectmolecular-cloningen_US
dc.subjectepidemicen_US
dc.subjectsequenceen_US
dc.subjectseroreactivityen_US
dc.subjectantibodyen_US
dc.subjectoutbreaken_US
dc.subjectmexicoen_US
dc.titleClinical and epidemiological implications of swine hepatitis E virus infectionen_US
dc.typeJournal Articlezh_TW
dc.identifier.doi10.1002/(sici)1096-9071(200002)60:2<166::aid-jmv10>3.0.co;2-8zh_TW
item.grantfulltextnone-
item.fulltextno fulltext-
item.cerifentitytypePublications-
item.languageiso639-1en_US-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeJournal Article-
Appears in Collections:生命科學系所
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