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dc.contributor.authorShin, Chun-Yuanen_US
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dc.description.abstract水在藥物經皮輸送系統中是常用的溶劑同時也是化學促滲劑(chemical enhancer),因此探討水對皮膚的影響,是一項值得探討的題目。在研究結果,我們希望能夠求得一系列不同親脂性藥物的有效滲透係數,各個藥物都將有一系列滲透係數在時間影響下的變化值,這項方法將幫助我們了解水合作用對藥物經皮傳遞之影響。本研究主要目的是希望使用簡易且精確的數值模型擬合(curve fitting)求得各類藥物之有效滲透係數,在能夠求得精準的滲透係數之前提下,我們希望能夠藉此量化在水合作用下各種不同親脂性(Ko/w)藥物之有效滲透係數變化程度,並試圖了解皮膚水合作用的機制。探討48小時內皮膚水合作用之實驗,期間以兩小時為間隔取得各個時間點之藥物累積滲透量,之後將此數據與數值模型進行擬合得到隨著時間產生變化之有效滲透係數。zh_TW
dc.description.abstractWater not only serves as a solvent, but also is a chemical penetration enhancer in transdermal drug delivery system. Therefore, the hydration of skin is an important topic. In the study, we aim at obtaining a series of effective permeability coefficients of drugs, with a range of lipophilicity along with the corresponding drug release curves, which provide an important approach for the investigation of the effect of hydration on transdermal drug delivery. The main purpose of this study is to use a simple and accurate numerical model to fit the effective permeability coefficient for various drugs. as the precise quantification of effective permeability is obtained, attempts are made to elucidate the mechanism for the hydration of skin impacting the effective permeability of skin. And drugs of various lipophilicity(termed Ko/w) are investigated to study the correlation between lipophilicity of drug molecules and the hydration of the stratum corneum layer.en_US
dc.description.tableofcontents摘要 I ABSTRACT II 目錄 III 圖目錄 V 表目錄 VII 第一章 前言 1 第二章 文獻回顧 2 第一節 經皮給藥系統 2 第二節 皮膚結構 5 一、 真皮層 6 二、 皮下組織 6 三、 表皮層 7 第三節 經皮給藥途徑 8 一、 直接穿透角質細胞途徑(Transcellular Route) 9 二、 附屬器途徑(Appendage Route) 9 三、 角質細胞間隙途徑(Intercellular Route) 10 第四節 經皮滲透原理 10 第五節 促進藥物滲透 15 第六節 水合作用 17 第七節 藥品性質與用途 19 一、 水楊酸(Salicylate, SA) 19 二、 苯甲酸(Benzoic acid, BA) 19 三、 間-苯二酚(Resorcinol, RE) 19 四、 5-氟尿嘧啶(5-fluorouracil, FL) 19 第三章 實驗方法與材料 21 第一節 實驗方法 21 一、 48小時-檢測水合作用對有效滲透係數影響之實驗 21 二、 12小時皮膚熱處理之實驗 21 第二節 皮膚樣品製備 24 一、 豬皮樣品(porcine skin) 24 二、 小鼠皮膚樣品(mouse skin) 24 第三節 經皮滲透實驗步驟 25 一、 Franz Diffusion Cell (FDC) 25 二、 取樣 25 第四節 HPLC定量方法 26 一、 器配備及設定參數 26 二、 操作步驟: 27 三、 分析條件 27 第五節 數值模型分析擬合程式 30 第六節 最小平方和法 33 第七節 實驗藥品 33 第八節 實驗儀器 34 第四章 實驗結果 35 第一節 標準曲線 35 第二節 分析方法之精密度 37 一、 水楊酸同日間與異日間之精密度: 37 二、 5-氟尿嘧啶同日間與異日間之精密度: 38 三、 苯甲酸同日間與異日間之精密度: 38 四、 間-苯二酚同日間與異日間之精密度: 39 第三節 藥品累積滲透量 39 一、 48小時經皮滲透實驗數據 39 二、 間-苯二酚以及水楊酸於正常鼠皮與熱處理鼠皮之經皮滲透實驗 52 第四節 多區間擬合之數值模型模擬 57 一、 最小誤差平方和法與平移時間常數 57 二、 數值模擬結果 59 第五節 鼠皮滲透實驗之有效滲透係數定量 64 一、定量方法 64 二、定量結果 65 第五章 討論 68 第一節 藥物之有效滲透係數 68 一、 藉由QSPRs比較有效滲透係數 68 二、 探討熱處理對角質層阻抗之影響 70 第二節 有效滲透係數於水合條件之探討 71 第三節 定量方法 75 第六章 結論與未來展望 78 第七章 參考文獻 79 附錄 84zh_TW
dc.subjectheat treatmenten_US
dc.subjecteffective permeabilityen_US
dc.titleThe Effect of Stratum Corneum Hydration on Transdermal Drug Delivery Processen_US
dc.typeThesis and Dissertationzh_TW
item.openairetypeThesis and Dissertation-
item.fulltextno fulltext-
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