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標題: 水解反應對藥物經皮傳輸程序的影響之探討
Research in the Effect of Hydrolysis Reaction in the Transdermal Drug Delivery Process
作者: 褚鴻霖
Chu, Hong-Lin
關鍵字: Drug transdermal delivery;藥物經皮傳輸;Aspirin;Hydrolysis reaction;阿斯匹靈;水解反應
出版社: 化學工程學系所
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The transdermal permeation of Aspirin associated with its hydrolysis reaction during the mass transfer process was studied in both experimental and modeling aspects. Using the Fickian diffusion model with two model variables, which represented effective skin permeability and the first-order hydrolysis rate constant in the skin, transdermal drug delivery process was quantified. This work characterizes the effect of numerical parameters in transport of the drug molecules across the skin, and deduces that the delivery efficiency has to be improved by using appropriate dosage form or permeation enhancement for the drug molecules that might encounter hydrolysis reaction during its percutaneous permeation. At the same time, our refined numerical model takes the hydrolysis reaction into consideration respectively at the zones of the donor solution, the skin tissue and the acceptor solution. The impacts of the reaction in these zones on the overall transdermal permeation are evaluated separately. The numerical model also provides a quantitative base for the application on transdermal drug delivery system, especially for these with chemical reaction in parallel with skin permeation.
其他識別: U0005-1908201015403000
Appears in Collections:化學工程學系所

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