Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/38344
DC FieldValueLanguage
dc.contributor.authorWang, A.L.en_US
dc.contributor.author劉英明zh_TW
dc.contributor.authorLiou, Y.M.en_US
dc.contributor.authorPawlak, C.R.en_US
dc.contributor.authorHo, Y.J.en_US
dc.date2010zh_TW
dc.date.accessioned2014-06-06T08:00:43Z-
dc.date.available2014-06-06T08:00:43Z-
dc.identifier.issn0166-4328zh_TW
dc.identifier.urihttp://hdl.handle.net/11455/38344-
dc.description.abstractHyper-activation of glutamatergic activity and deficits in episodic memory has been observed in Parkinson's disease (PD). This study was intended to clarify the effects of D-cycloserine (DCS), a partial agonist of N-methyl-D-aspartate (NMDA) receptors, on neuroinflammation and deficits in episodic-like memory in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD animal model. Male Wistar rats were stereotaxically administered with MPTP into the substantia nigra pars compacta. Starting 1 day after the lesion. animals were treated daily with DCS (0, 5, or 10 mg/kg/day; i.p.). Thirteen days after the MPTP lesion, the rats received the episodic-like memory test. Sham-operated rats exhibited episodic-like memory, recognizing objects' location and objects' temporal order. MPTP-lesioned rats exhibited deterioration in spatial memory and failed to recognize the temporal order of objects. Further, MPTP lesions resulted in dopaminergic degeneration and microglial activation in the brain, as well as cell loss in the hippocampal CA1 area. DCS treatment (10 mg/kg/day) reversed the above neurodegeneration, neuroinflammation, and behavioral deficits. Taken together, these results suggest that NMDA receptors may be involved in cognitive deficits in PD and that the application of DCS in the treatment for dementia in PD is warranted. (C) 2009 Elsevier B.V. All rights reserved.en_US
dc.language.isoen_USzh_TW
dc.relationBehavioural Brain Researchen_US
dc.relation.ispartofseriesBehavioural Brain Research, Volume 208, Issue 1, Page(s) 38-46.en_US
dc.relation.urihttp://dx.doi.org/10.1016/j.bbr.2009.11.006en_US
dc.subjectParkinson's diseaseen_US
dc.subjectNMDA receptorsen_US
dc.subjectEpisodic-like memoryen_US
dc.subjectD-Cycloserineen_US
dc.subjectNeuroinflammationen_US
dc.subjectCognitionen_US
dc.subjectglycine modulatory siteen_US
dc.subjectspatial working-memoryen_US
dc.subjectd-aspartate receptoren_US
dc.subjectnigra pars compactaen_US
dc.subjectd-cycloserineen_US
dc.subjectparkinsons-diseaseen_US
dc.subjectrecognitionen_US
dc.subjectmemoryen_US
dc.subjectsubstantia-nigraen_US
dc.subjectobject recognitionen_US
dc.subjectalzheimers-diseaseen_US
dc.titleInvolvement of NMDA receptors in both MPTP-induced neuroinflammation and deficits in episodic-like memory in Wistar ratsen_US
dc.typeJournal Articlezh_TW
dc.identifier.doi10.1016/j.bbr.2009.11.006zh_TW
item.grantfulltextnone-
item.openairetypeJournal Article-
item.languageiso639-1en_US-
item.fulltextno fulltext-
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
Appears in Collections:生命科學系所
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