Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/38387
DC FieldValueLanguage
dc.contributor.authorSy, H.N.en_US
dc.contributor.author劉英明zh_TW
dc.contributor.authorWu, S.L.en_US
dc.contributor.authorWang, W.F.en_US
dc.contributor.authorChen, C.H.en_US
dc.contributor.authorHuang, Y.T.en_US
dc.contributor.authorLiou, Y.M.en_US
dc.contributor.authorChiou, C.S.en_US
dc.contributor.authorPawlak, C.R.en_US
dc.contributor.authorHo, Y.J.en_US
dc.date2010zh_TW
dc.date.accessioned2014-06-06T08:00:46Z-
dc.date.available2014-06-06T08:00:46Z-
dc.identifier.issn0091-3057zh_TW
dc.identifier.urihttp://hdl.handle.net/11455/38387-
dc.description.abstractEmotional changes, impairment of object recognition, and neuroinflammation are seen in Parkinson's disease with dementia (POD). Here, we show that bilateral infusion of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) into the rat substantia nigra pars compacts (SNc) of Wistar rats caused degeneration of nigrostriatal dopaminergic neurons, microglial activation in the SNc and hippocampus, and cell loss in the hippocampal CA1 area. With regard to behavior, an increase in anxiety-like behavior and impairment of object recognition were observed during the fourth week after MPTP lesioning. The behavioral changes were not caused by motor impairment, since the rats had already recovered from MPTP-induced catalepsy before the tests were performed. These findings show that MPTP-induced neuroinflammation and its consequences, for example, microglial activation and cell loss in the hippocampus, may be involved in dopaminergic degeneration-related behavioral deficits and suggest that, in addition to the dopaminergic system, the limbic system may also participate in the pathophysiology of POD. MPTP-lesioned rats are therefore proposed as a useful tool for assessing the ability of pharmacological agents to prevent recognition deficits in POD. (C) 2010 Elsevier Inc. All rights reserved.en_US
dc.language.isoen_USzh_TW
dc.relationPharmacology Biochemistry and Behavioren_US
dc.relation.ispartofseriesPharmacology Biochemistry and Behavior, Volume 95, Issue 2, Page(s) 158-165.en_US
dc.relation.urihttp://dx.doi.org/10.1016/j.pbb.2009.12.020en_US
dc.subjectParkinson's diseaseen_US
dc.subjectDementiaen_US
dc.subjectObject recognitionen_US
dc.subjectNeuroinflammationen_US
dc.subjectMicroglial activationen_US
dc.subjectMPTPen_US
dc.subjectearly parkinsons-diseaseen_US
dc.subjectnigra pars compactaen_US
dc.subjectnmda receptor subunitsen_US
dc.subjectepisodic-like memoryen_US
dc.subjectsubstantia-nigraen_US
dc.subjectmicroglial activationen_US
dc.subjectd-cycloserineen_US
dc.subjectwistar ratsen_US
dc.subjectneurodegenerative diseasesen_US
dc.subjectvisualen_US
dc.subjecthallucinationsen_US
dc.titleMPTP-induced dopaminergic degeneration and deficits in object recognition in rats are accompanied by neuroinflammation in the hippocampusen_US
dc.typeJournal Articlezh_TW
dc.identifier.doi10.1016/j.pbb.2009.12.020zh_TW
item.openairetypeJournal Article-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.fulltextno fulltext-
item.cerifentitytypePublications-
item.languageiso639-1en_US-
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