Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/38489
DC FieldValueLanguage
dc.contributor.author蘇鴻麟zh_TW
dc.contributor.authorChuang, C.S.en_US
dc.contributor.authorSu, H.L.en_US
dc.contributor.authorCheng, F.C.en_US
dc.contributor.authorHsu, S.H.en_US
dc.contributor.authorChuang, C.F.en_US
dc.contributor.authorLiu, C.S.en_US
dc.date2010zh_TW
dc.date.accessioned2014-06-06T08:00:51Z-
dc.date.available2014-06-06T08:00:51Z-
dc.identifier.issn1021-7770zh_TW
dc.identifier.urihttp://hdl.handle.net/11455/38489-
dc.description.abstractAlthough gait change is considered a useful indicator of severity in animal models of Parkinson's disease, systematic and extensive gait analysis in animal models of neurological deficits is not well established. The CatWalk-assisted automated gait analysis system provides a comprehensive way to assess a number of dynamic and static gait parameters simultaneously. In this study, we used the Catwalk system to investigate changes in gait parameters in adult rats with unilateral 6-OHDA-induced lesions and the rescue effect of dopaminergic neuron transplantation on gait function. Four weeks after 6-OHDA injection, the intensity and maximal area of contact were significantly decreased in the affected paws and the swing speed significantly decreased in all four paws. The relative distance between the hind paws also increased, suggesting that animals with unilateral 6-OHDA-induced lesions required all four paws to compensate for loss of balance function. At 8 weeks post-transplantation, engrafted dopaminergic neurons expressed tyrosine hydroxylase. In addition, the intensity, contact area, and swing speed of the four limbs increased and the distance between the hind paws decreased. Partial recovery of methamphetamine-induced rotational response was also noted.en_US
dc.language.isoen_USzh_TW
dc.relationJournal of Biomedical Scienceen_US
dc.relation.ispartofseriesJournal of Biomedical Science, Volume 17.en_US
dc.relation.urihttp://dx.doi.org/10.1186/1423-0127-17-9en_US
dc.subjecthigh-frequency stimulationen_US
dc.subjectspinal-cord-injuryen_US
dc.subjectgait analysisen_US
dc.subjectsubthalamic nucleusen_US
dc.subjectnigrostriatal pathwayen_US
dc.subjectsubstantia-nigraen_US
dc.subject6-hydroxydopamineen_US
dc.subjectcellen_US
dc.subjectlocomotionen_US
dc.subjecttransplantationen_US
dc.titleQuantitative evaluation of motor function before and after engraftment of dopaminergic neurons in a rat model of Parkinson's diseaseen_US
dc.typeJournal Articlezh_TW
dc.identifier.doi10.1186/1423-0127-17-9zh_TW
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextno fulltext-
item.cerifentitytypePublications-
item.grantfulltextnone-
item.languageiso639-1en_US-
item.openairetypeJournal Article-
Appears in Collections:生命科學系所
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