Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/38492
DC FieldValueLanguage
dc.contributor.author蘇鴻麟zh_TW
dc.contributor.authorChen, C.W.en_US
dc.contributor.authorLiu, C.S.en_US
dc.contributor.authorChiu, I.M.en_US
dc.contributor.authorShen, S.C.en_US
dc.contributor.authorPan, H.C.en_US
dc.contributor.authorLee, K.H.en_US
dc.contributor.authorLin, S.Z.en_US
dc.contributor.authorSu, H.L.en_US
dc.date2010zh_TW
dc.date.accessioned2014-06-06T08:00:52Z-
dc.date.available2014-06-06T08:00:52Z-
dc.identifier.issn1021-7770zh_TW
dc.identifier.urihttp://hdl.handle.net/11455/38492-
dc.description.abstractBackground: Neural induction is a complex process and the detailed mechanism of FGF-induced neurogenesis remains unclear. Methods: By using a serum-free neural induction method, we showed that FGF1 dose-dependently promoted the induction of Sox1/N-cadherin/nestin triple positive cells, which represent primitive neuroblasts, from mouse embryonic stem (ES) cells. Results: We demonstrated that FGF1, FGF2, and FGF4, but not FGF8b, enhanced this neurogenesis. Especially, FGF-enhanced neurogenesis is not mediated through the rescue of the apoptosis or the enhancement of the proliferation of Sox1(+) cells. We further indicated that the inactivation of c-Jun N-terminal kinase-1 (JNK-1) and extracellular signal-related kinase-2 (ERK-2), but not p38 mitogen-activated protein kinase (MAPK), inhibited the neural formation through the inhibition of ES differentiation, but not through the formation of endomesodermal cells. Conclusions: These lines of evidence delineated the roles of FGF downstream signals in the early neural differentiation of ES cells.en_US
dc.language.isoen_USzh_TW
dc.relationJournal of Biomedical Scienceen_US
dc.relation.ispartofseriesJournal of Biomedical Science, Volume 17.en_US
dc.relation.urihttp://dx.doi.org/10.1186/1423-0127-17-33en_US
dc.subjectjun nh2-terminal kinaseen_US
dc.subjectneural inductionen_US
dc.subjectdirected differentiationen_US
dc.subjectbmpen_US
dc.subjectinhibitionen_US
dc.subjectself-renewalen_US
dc.subjectneuronsen_US
dc.subjectmouseen_US
dc.subjectprecursorsen_US
dc.subjectchicken_US
dc.subjectgastrulationen_US
dc.titleThe signals of FGFs on the neurogenesis of embryonic stem cellsen_US
dc.typeJournal Articlezh_TW
dc.identifier.doi10.1186/1423-0127-17-33zh_TW
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.languageiso639-1en_US-
item.openairetypeJournal Article-
item.grantfulltextnone-
item.fulltextno fulltext-
item.cerifentitytypePublications-
Appears in Collections:生命科學系所
Show simple item record
 

Google ScholarTM

Check

Altmetric

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.