Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/3896
DC FieldValueLanguage
dc.contributor鄭文桐zh_TW
dc.contributor施志欣zh_TW
dc.contributor.advisor張厚謙zh_TW
dc.contributor.author謝明哲zh_TW
dc.contributor.authorShieh, Ming-Cheen_US
dc.contributor.other中興大學zh_TW
dc.date2012zh_TW
dc.date.accessioned2014-06-06T05:33:02Z-
dc.date.available2014-06-06T05:33:02Z-
dc.identifierU0005-1508201116254200zh_TW
dc.identifier.citation[1] Arifin, D. Y., Lee, L. Y., Wang, C. H., Mathematical modeling and simulation of drug release from microspheres: Implications to drug delivery systems, Advanced drug delivery reviews, 58 12-13 (2006) 1274-1325. [2] Baker, R. W., Membrane technology and applications, Wiley, (2000). [3] Banker, G. S., Rhodes, C. T., Modern pharmaceutics, Informa HealthCare, (2002). [4] Barnes, D. W., Pharmacology, Philadelphia :Mosby Elsevier, (2006). [5] Bird, R. B., Transport phenomena, Applied Mechanics Reviews, 55 (2002) R1. [6] Chiwele, I., Jones, B. E., Podczeck, F., The shell dissolution of various empty hard capsules, CHEMICAL AND PHARMACEUTICAL BULLETIN-TOKYO-, 48 7 (2000) 951-956. [7] Ciper, M., Bodmeier, R., Modified conventional hard gelatin capsules as fast disintegrating dosage form in the oral cavity, European journal of pharmaceutics and biopharmaceutics, 62 2 (2006) 178-184. [8] Cole, E. T., Cade, D., Benameur, H., Challenges and opportunities in the encapsulation of liquid and semi-solid formulations into capsules for oral administration, Advanced drug delivery reviews, 60 6 (2008) 747-756. [9] Cole, E. T., Scott, R. A., Connor, A. L., Wilding, I. R., Petereit, H. U., Schminke, C., Beckert, T., Cade, D., Enteric coated HPMC capsules designed to achieve intestinal targeting, International journal of pharmaceutics, 231 1 (2002) 83-95. [10] Cole, G., Capsule types, filling tests, and formulation, Hard capsules, Ed. Ridgway, K. The Pharmaceutical Press, London, (1987). [11] Cole, G., Evaluating Development and Production Costs: Tablets, Pharmaceutical Technology Europe, 5 (1998) 17-26. [12] Crank, J., The mathematics of diffusion, Oxford University Press, (1983). [13] Cussler, E. L., Diffusion: Mass transfer in fluid systems, Cambridge Univ Pr, (1997). [14] Du, C., Zhou, J., Shaviv, A., Wang, H., Mathematical model for potassium release from polymer-coated fertiliser, Biosystems engineering, 88 3 (2004) 395-400. [15] Ewart, T., Liquid filled and sealed hard gelatin capsules. [16] Felton, L., Shah, N., Zhang, G., Infeld, M., Malick, A., McGinity, J., Physical-mechanical properties of film-coated soft gelatin capsules, International journal of pharmaceutics, 127 2 (1996) 203-211. [17] Gullapalli, R. P., Soft gelatin capsules (softgels), Journal of Pharmaceutical Sciences, 99 10 (2010) 4107-4148. [18] Guo, M., Kalra, G., Wilson, W., Peng, Y., Augsburger, L. L., Hard Gelatin Capsule Formulation Development, Pharmaceutical technology, (2002). [19] Hirani, J. J., Rathod, D. A., Vadalia, K. R., Orally disintegrating tablets: A review, Tropical Journal of Pharmaceutical Research, 8 2 (2009). [20] Jones, B., Disintegration of hard gelatin capsules, Acta pharmaceutica Suecica, 9 3 (1972) 261. [21] Jones, B. E., Manufacture and properties of two-piece hard capsules, Pharmaceutical capsules, (2004). [22] Koizumi, T., Ritthidej, G. C., Phaechamud, T., Mechanistic modeling of drug release from chitosan coated tablets, Journal of controlled release, 70 3 (2001) 277-284. [23] Ludwig, A., Van Ooteghem, M., Disintegration of Hard Gelatin Capsules, part 2: Disintegration mechanism of hard gelatin capsules investigated with a stereoscopic microscope, Pharm. Ind, 42 (1980) 405-406. [24] Pina, M., Sousa, A., Brojo, A., Enteric coating of hard gelatin capsules. Part 1. Application of hydroalcoholic solutions of formaldehyde in preparation of gastro-resistant capsules, International journal of pharmaceutics, 133 1-2 (1996) 139-148. [25] Pina, M., Sousa, A., Brojo, A., Enteric coating of hard gelatin capsules. Part 2--Lioavailability of formaldehyde treated capsules, International journal of pharmaceutics, 148 1 (1997) 73-84. [26] Podczeck, F., Pharmaceutical capsules, Pharmaceutical Pr, (2004). 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R., Venugopal, K., Manikandan, R., Alteration in Dissolution Characteristics of Gelatin-Containing Formulations, Pharmaceutical technology, (2002). [34] Stegemann, S., CAPSUGEL, Hard Gelatin Capsules Today-and Tomorrow, Capsugel Library, (1999). [35] Thoma, K., Bechtold, K., CAPSUGEL, Enteric coated hard gelatin capsules, Capsugel Library, (1992). [36] Vilivalam, V. D., Illum, L., Iqbal, K., Starch capsules: an alternative system for oral drug delivery, Pharmaceutical Science & Technology Today, 3 2 (2000) 64-69. [37] Winfield, A. J., Rees, J. A., Smith, I., Pharmaceutical Practice, Churchill Livingstone/Elsevier, (2009). [38] Zilberman, M., Sofer, M., A mathematical model for predicting controlled release of bioactive agents from composite fiber structures, Journal of Biomedical Materials Research Part A, 80 3 (2007) 679-686.en_US
dc.identifier.urihttp://hdl.handle.net/11455/3896-
dc.description.abstract在疾病的治療過程中,藥物的使用是不可或缺的一環,在藥物的使用上,要達到控制藥物釋放又是一門重要的學問。藥物的載體以錠劑及膠囊兩種劑型為大宗,其中又以膠囊劑型為最常使用之載體,這是由於膠囊的靈活性,填充藥物的狀態可多變,不管是固體藥物或是液體藥物,甚至是半固體藥物,均可充填至膠囊內,使藥物不致洩露出來。因此了解膠囊藥物的釋放極為重要,本研究主要目的即是推導出膠囊釋放之數值模型,再以此數值模型與膠囊的釋放曲線進行擬合,定量出有效擴散係數和遲滯時間。實驗中的膠囊有以下幾種不同的控制變因,包含腰帶的有無、封膜的有無、充填物的飽滿度、以及不同釋放環境,針對不同類型的膠囊所得到的釋放曲線,與數值模型擬合,得到該情況下之遲滯時間,以及有效擴散係數。zh_TW
dc.description.abstractStudy of drug release for treatment of disease is very important, the utility drug carriers such as tablet and capsule, the latter is more practical than the former. Owing to adaptability of the capsules, it is changeful in the filling types of drugs. No matter what the filling types of drugs are solid, liquid, or semi-solid, a drug filled into a capsule is completely. Consequently, it is more important for everyone to study the capsule-drug release. In this study, we derived a mathematical model to describe the drug release in capsule, and to quantify the effective diffusion coefficient and lag time with the experimental data. During experiment, the capsules had different types, including with or without belt and film, full degree of the drug, and the different kinds of bulk solution. Then, the mathematical model was fitting with data, therefore, obtained the effective diffusion coefficient and lag time in each case.en_US
dc.description.tableofcontents摘要 I Abstract II 目錄 III 圖目錄 V 表目錄 VII 第一章 前言 1 第二章 文獻回顧 2 2-1 給藥系統 2 2-1-1 給藥途徑 2 2-1-2 給藥動力學 4 2-2 口服藥劑 4 2-2-1 口服藥物劑型的發展 5 2-2-2 口服藥劑 5 2-2-3 口服藥品劑型 6 2-3 膠囊 6 2-3-1 膠囊的發展 6 2-3-2 膠囊的種類 7 2-3-3 軟膠囊 10 2-3-4 軟膠囊的優勢 10 2-3-5 硬膠囊 11 2-3-6 硬膠囊的優勢 14 2-4 藥物釋放行為 16 第三章 藥物釋放模型 19 3-1 符號 19 3-2 數值模型 20 3-3 膠囊殼層(無腰帶) 26 3-4 藥物溶解的量 27 3-5 膠囊殼層(腰帶) 28 3-6 膠囊殼層(封膜) 29 3-7 最小均方根 31 3-8 擬合流程圖 31 3-9 參數設定 33 第四章 實驗結果 34 4-1 標準曲線 34 4-2 膠囊的編號 34 4-3 膠囊藥物的釋放(無封膜) 36 4-4 膠囊藥物的釋放(有封膜) 45 第五章 實驗結果討論 54 5-1 探討膠囊的飽滿度與尺寸 54 5-2 探討膠囊於不同的釋放環境 56 5-3 探討膠囊的腰帶 59 5-4 探討膠囊的封膜. 62 第六章 結論與未來展望 63 第七章 參考文獻 64 附錄 67zh_TW
dc.language.isoen_USzh_TW
dc.publisher化學工程學系所zh_TW
dc.relation.urihttp://www.airitilibrary.com/Publication/alDetailedMesh1?DocID=U0005-1508201116254200en_US
dc.subjectCapsuleen_US
dc.subject膠囊zh_TW
dc.subjectMathematical modelen_US
dc.subject數值模型zh_TW
dc.title利用數值模型定量膠囊釋放之行為zh_TW
dc.titleThe Quantification of Capsule-Drug Release with a Mathematical Modelen_US
dc.typeThesis and Dissertationzh_TW
item.grantfulltextnone-
item.fulltextno fulltext-
item.cerifentitytypePublications-
item.languageiso639-1en_US-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeThesis and Dissertation-
Appears in Collections:化學工程學系所
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