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標題: 以聚乳酸二元醇製備兼具生物可分解及生物相容性之聚胺酯/尿素
Synthesis of Biodegradable and Biocompatible Polyurethane/urea Containing Polylactiode Diol
作者: 林惠美
Lin, Hui-Mei
關鍵字: Polylactide diol;聚乳酸二元醇;Biodegradable;Biocompatible;Polyurethane;生物可分解;生物相容性;聚胺酯
出版社: 化學工程學系所
引用: 1.日本生物可分解塑膠研究會,圖解生物可分解塑膠,世茂出版有限公司(2006)。 2.張敏; 崔春娜; 宋潔; 邱建輝 包裝工程,2008,29,16-18。 3.張豐志,應用高分子手冊,五南圖書出版社(2003)。 4.S. A., Guelcher An Introduction to Biomaterials, Guelcher, S.A., Hollinger, J.O., Eds., CRC/Taylor & Francis: Boca Raton, FL, 2006. 5.Z. Wirpsza, Polyurethanes: Chemistry, Technology, and Applications; Polymer Science and Technology Series; E. Horwood: New York, 1993. 6.K. Gorna; S. Gogolewski, Polymer Degradation and Stability, 2003, 79, 475-485. 7.T. Thomson, Polyurethanes as Specialty Chemicals: Principles and Applications, CRC Press: Boca Raton, Fla., 2005. 8.馮亞凱; 吳珍珍, Materials Review, 2006, 20, 115-118. 9.S. A. Guelcher, Tissue Engineering Part B: Reviews, 2008, 14, 3-17. 10.賴耿陽,聚脲酯樹脂PU原理與實用,復漢出版社(2001)。 11.E. T. H. Vink; K. R. Rabago; D. A. Glassner; P. R. Gruber, Polymer Degradation and Stability, 2003, 80, 403-419. 12.S. Inkinen; M. Hakkarainen; A. C. Albertsson; A. Sodergard, Biomacromolecules, 2011. 12, 523-532. 13.R. Mehta; V. Kumar; H. Bhunia; S. N. Upadhyay, Journal of Macromolecular Science, Part C: Polymer Reviews, 2005, 45, 325-349. 14.陳佑星,碩士論文,國立中興大學化學工程系(2010)。 15.D. L. Kaplan, Biopolymers from Renewable Resources, Springer-Verlag, New York, 1998. 16.李圓圓、陳昀,合成纖維工業,2009,32,23-26。 17.K. Stridsberg; M. Ryne; A. Albertsson, Macromolecules, 2000, 3, 2862-2869. 18.M. Nagata; Y. Sato, Polymer International, 2005, 54, 386-391. 19.W. S. Wang; P. Ping; X. S. Chen; X. B. Jing, European Polymer Journal, 2006, 42, 1240-1249. 20.W. S. Wang; P. Ping; X. S. Chen; X. B. Jing, Polymer International, 2007, 56, 840-846. 21.平鵬、王文首、章培標、陳學思、景遐斌,高等學校化學學報,2007,28,371-375。 22.W. S. Wang; P. Ping; X. S. Chen; X. B. Jing, Journal of Applied Polymer Science, 2007, 104, 4182-4187. 23.Y. L. Wang; Y. G. Li; Y. F. Luo; M. N. Huang; Z. Q. Liang, Materials Letters, 2009, 63, 347-349. 24.B. C. Chun; T. K. Cho; Y. C. Chung, European Polymer Journal, 2006, 42, 3367-3373. 25.E. Yilgor; I. Yilgor, Polymer, 2001, 42, 7953-7959. 26.H. S. Lee; Y. K. Wang; S. L. Hsu, Macromolecules, 1987, 20, 2089-2095. 27.L. Ning; W. D. Ning; Y. S. Kang, Macromolecules, 1997, 30, 4405-4409. 28.K. Lewandowski; L. R. Krepski; D. E. Michus; R. R. Roberts, S. M. Heilmann; W. K. Larson; M. D. Purgett; S. D. Koecher; S. A. Johnson; D. J. Mcgurran; C. J. Rreb; S. V. Pathre; K. A. M. Thakur, Journal of Polymer Science: Part A: Polymer Chemistry, 2002, 40, 3037-3045. 29.E. Ayres; R. L. Orefice; M. I. Yoshida, European Polymer Journal, 2007, 43, 3510-3521. 30.O. Gunter, Polyurethane Handbook, (1994).
本研究主要探討如何利用化學合成方式,結合聚乳酸二元醇(PLA-diol-2000)與聚胺酯(Polyurethane, PU),設計出一種新型的綠色材料。首先利用1,4-丁二醇(1,4-Butandiol, 1,4-BDO)作為起始劑,與L型乳酸交酯(L-Lactide)進行開環聚合(Ring-Opening Polymerization, ROP),可合成出Mn約為1,800 g/mol之L型聚乳酸二元醇(PLA-diol-2000),並以此做為PU軟鏈段中重要的組成。而配方當中,其他的原料則選用聚酯二元醇(Diol of Polyethylene-Butylene-Adipate, RS-956)、聚四亞甲基醚二醇(Polytetramethylene Ether Glycol, PTMEG-2000)、異弗爾酮二異氰酸鹽(Isophorone Diisocyanate, IPDI)、1,4-丁二醇及1,4-丁二胺(1,4-Butanediamine, 1,4-BDA)。

In this study, we have combined the chemical processing of PLA-diol-2000 into polyurethanes (PUs) in our design of new green materials. PLA-diol-2000 of 1,800 molecular weight was synthesized from 1,4-butanediol and L-lactide through ring-opening polymerization, and was used as the key component of soft segment of PUs. Other common raw materials used in our formulation developments were diol of polyethylene-butylene-adipate (RS-956), polytetramethylene ether glycol (PTMEG), isophorone diisocyanate (IPDI), 1,4-butanediol (1,4-BDO) and 1,4-butanediamine (1,4-BDA).
The suitable process for synthesis of PUs with PLA-diol-2000 was studied, and the characteristics of synthesized PUs containing PLA-diol-2000 were analyzed, including molecular weights, thermal properties and mechanical properties. From this study, we have come up with PUs possessing balanced properties that exhibit excellent biocompatibility and biodegradability. This is achieved by the combination of PLA-diol-2000/PTMEG/RS-956 (in ratio of 1/1/3, respectively) as the soft segment constituents with BDO and BDA (in ratio of 1/1, respectively) as the hard segment ingredients in our formulation. The green materials show great potential for use in the special medical applications.
其他識別: U0005-1608201117444000
Appears in Collections:化學工程學系所

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