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dc.contributor.authorYao, Li-Yuen_US
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dc.description.abstractThe Oral Drug Delivery System (ODDS) is designed to control drug release by maintaining the drug concentration constant in blood and reaching the optimal efficacy. The most effective implementation of control release is to coat the drug with designed material which is sensitive to certain conditions e.g., pH values, release time, etc. Among the variety of coating methods, capsulation is the mostly employed. This work investigate the common manipulated parameters of capsulation, including drug filling amount, capsule size, conditions of bulk solution, sealing, and coating. The electrical conductivity method was used to determine the drug concentration for its satisfactory accuracy, convenience and relatively low cost compared to High Performance Liquid Chromatography (HPLC). With the mathematical model, the quantification of the drug release from capsules is thus feasible.en_US
dc.description.tableofcontents目錄 摘要 i ABSTRACT ii 目錄 iii 表目錄 v 圖目錄 vi 第一章 緒論 1 第一節 前言 1 第二節 研究目的 1 第二章 文獻回顧 4 第一節 藥物傳輸系統 4 一、 原理 4 二、 藥物傳輸類型 4 第二節 口服劑介紹 7 一、 常見的口服藥物劑型 7 二、 膠囊的由來 9 三、 膠囊的分類 10 第三節 膠囊腰帶 17 第三章 實驗設計 19 第一節 實驗流程 19 一、 實驗方法 19 二、 膠囊之填充處理 25 三、 膠囊藥物釋放實驗步驟 25 四、 膠囊填充物含水量測定步驟 27 第二節 實驗藥品 28 第三節 實驗儀器 28 第四章 研究結果 29 第一節 標準曲線 29 第二節 膠囊釋放釋放累積濃度 30 一、 膠囊填充飽滿度實驗數據 30 二、 膠囊大小實驗數據 34 三、 膠囊釋放環境實驗數據 39 四、 膠囊腰帶實驗數據 43 五、 膠囊膜衣實驗數據 48 六、 水分含量測定實驗數據 52 第三節 量化膠囊擴散係數 55 一、 量化後數值 55 二、 最小根均方誤差法 56 三、 數據擬合結果 57 第五章 討論 60 第一節 膠囊填充飽滿度 60 第二節 膠囊大小 61 第三節 膠囊釋放環境 62 第四節 膠囊腰帶 63 第六章 結論與未來展望 66 第七章 參考文獻 67zh_TW
dc.subjectdrug releaseen_US
dc.titleThe Quantitative Research of Drug Release for Hard Capsulesen_US
dc.typeThesis and Dissertationzh_TW
item.openairetypeThesis and Dissertation-
item.fulltextno fulltext-
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