Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/3945
DC FieldValueLanguage
dc.contributor廖國智zh_TW
dc.contributor施志欣zh_TW
dc.contributor.advisor張厚謙zh_TW
dc.contributor.authorYao, Li-Yuen_US
dc.contributor.author姚立羽zh_TW
dc.contributor.other中興大學zh_TW
dc.date2012zh_TW
dc.date.accessioned2014-06-06T06:25:06Z-
dc.date.available2014-06-06T06:25:06Z-
dc.identifierU0005-1608201114215600zh_TW
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Drug release behavior and preparation of microspheres composed of hydrophilic/hydrophobic blends of ethylcellulose and hydroxypropylcellulose. 48. Yu, L. X., Lipka, E., Crison, J. R., and Amidon, G. L. (1996). Transport approaches to the biopharmaceutical design of oral drug delivery systems: prediction of intestinal absorption. Advanced drug delivery reviews 19, 359-376. 49. 2000Ó Torpac Inc. All rights reserved. Torpac is a registered trademark of Torpac Inc. 50. 吳信賢(2008),利用數值模型定量尿素經皮吸收之滲透係數,中興大學化工碩士論文 51. 王怡芳(2009),藥物分子結構在經皮吸收過程中所扮演的角色:以水楊酸和阿斯匹靈為例,中興大學化工碩士論文 52. http://www.lsbu.ac.uk/water/hygel.htmlzh_TW
dc.identifier.urihttp://hdl.handle.net/11455/3945-
dc.description.abstractThe Oral Drug Delivery System (ODDS) is designed to control drug release by maintaining the drug concentration constant in blood and reaching the optimal efficacy. The most effective implementation of control release is to coat the drug with designed material which is sensitive to certain conditions e.g., pH values, release time, etc. Among the variety of coating methods, capsulation is the mostly employed. This work investigate the common manipulated parameters of capsulation, including drug filling amount, capsule size, conditions of bulk solution, sealing, and coating. The electrical conductivity method was used to determine the drug concentration for its satisfactory accuracy, convenience and relatively low cost compared to High Performance Liquid Chromatography (HPLC). With the mathematical model, the quantification of the drug release from capsules is thus feasible.en_US
dc.description.abstract口服藥物傳輸系統(ODDS),主要的目標都是為了達到控制釋放,使藥物在血液中濃度固定,使其發揮最大療效。藥物控制釋放常見的方式,一般多以將藥物用特殊的化學材質包覆,使藥物在某一種狀態下適時適量釋出,例如:PH值改變、延長釋放時間等。膠囊則是最早、最常見也最方便的一種藥物包覆方式。本研究針對常見的膠囊變因,例如:填充量、大小、釋放環境探討其釋放行為,更進一步探討目前硬膠囊足以取代軟膠囊的技術-腰帶(sealing),以及藥物走向控制釋放的關鍵-膜衣(coating)。將實驗結果配合數值模型量化出藥物的擴散係數。並由實驗結果知膠囊此類特殊構形之釋放行為。使用電導度法做定量,避免了一般光學儀器容易因為色素造成的影響,且其精確度與高效能液相層析儀定量法在同一數量級,又攜帶方便、實用。zh_TW
dc.description.tableofcontents目錄 摘要 i ABSTRACT ii 目錄 iii 表目錄 v 圖目錄 vi 第一章 緒論 1 第一節 前言 1 第二節 研究目的 1 第二章 文獻回顧 4 第一節 藥物傳輸系統 4 一、 原理 4 二、 藥物傳輸類型 4 第二節 口服劑介紹 7 一、 常見的口服藥物劑型 7 二、 膠囊的由來 9 三、 膠囊的分類 10 第三節 膠囊腰帶 17 第三章 實驗設計 19 第一節 實驗流程 19 一、 實驗方法 19 二、 膠囊之填充處理 25 三、 膠囊藥物釋放實驗步驟 25 四、 膠囊填充物含水量測定步驟 27 第二節 實驗藥品 28 第三節 實驗儀器 28 第四章 研究結果 29 第一節 標準曲線 29 第二節 膠囊釋放釋放累積濃度 30 一、 膠囊填充飽滿度實驗數據 30 二、 膠囊大小實驗數據 34 三、 膠囊釋放環境實驗數據 39 四、 膠囊腰帶實驗數據 43 五、 膠囊膜衣實驗數據 48 六、 水分含量測定實驗數據 52 第三節 量化膠囊擴散係數 55 一、 量化後數值 55 二、 最小根均方誤差法 56 三、 數據擬合結果 57 第五章 討論 60 第一節 膠囊填充飽滿度 60 第二節 膠囊大小 61 第三節 膠囊釋放環境 62 第四節 膠囊腰帶 63 第六章 結論與未來展望 66 第七章 參考文獻 67zh_TW
dc.language.isoen_USzh_TW
dc.publisher生醫工程研究所zh_TW
dc.relation.urihttp://www.airitilibrary.com/Publication/alDetailedMesh1?DocID=U0005-1608201114215600en_US
dc.subjectcapsuleen_US
dc.subject膠囊zh_TW
dc.subjectdrug releaseen_US
dc.subject藥物釋放zh_TW
dc.title膠囊設計對藥物釋放行為影響之定量研究zh_TW
dc.titleThe Quantitative Research of Drug Release for Hard Capsulesen_US
dc.typeThesis and Dissertationzh_TW
item.languageiso639-1en_US-
item.cerifentitytypePublications-
item.grantfulltextnone-
item.openairetypeThesis and Dissertation-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextno fulltext-
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