Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/40159
DC FieldValueLanguage
dc.contributor.authorLan, K.L.en_US
dc.contributor.author許美鈴zh_TW
dc.contributor.authorLan, K.H.en_US
dc.contributor.authorSheu, M.L.en_US
dc.contributor.authorChen, M.Y.en_US
dc.contributor.authorShih, Y.S.en_US
dc.contributor.authorHsu, F.C.en_US
dc.contributor.authorWang, H.M.en_US
dc.contributor.authorLiu, R.S.en_US
dc.contributor.authorYen, S.H.en_US
dc.date2011zh_TW
dc.date.accessioned2014-06-06T08:03:18Z-
dc.date.available2014-06-06T08:03:18Z-
dc.identifier.issn0955-3002zh_TW
dc.identifier.urihttp://hdl.handle.net/11455/40159-
dc.description.abstractPurpose: Hypoxia-inducible factor-1 alpha (HIF-1 alpha) plays a pivotal role in the reaction of a tumour to hypoxia. In this study, we examined the inhibitory effect of a natural compound, honokiol, on HIF-1 alpha activity and tumour growth in combination with radiation. Methods: The inhibitory effect of honokiol on hypoxia-responsive element (HRE) controlled luciferase activity and HIF-1 alpha accumulations stimulated by CoCl(2), or hypoxia was examined. Effect of honokiol on HIF-1 alpha levels within hypoxic tumour microenvironment was investigated by immunohistochemical and in vivo bioluminescent studies. The in vivo radio-sensitising activity of honokiol was evaluated with subcutaneous murine colon carcinoma, CT26, xenografts of BALB/c mice treated with honokiol, radiation, or both. Results: Suppression of luciferase (luc) activity in HRE-luc stable cells by honokiol was in agreement with the results of decreased HIF-1 alpha accumulation. In CT26-HRE-luc tumour-bearing mice, the inhibitory effect of intraperitoneally injected honokiol on HIF-1 alpha-regulated luciferase activities induced by either CoCl(2) or radiation could be monitored non-invasively. Lastly, honokiol in combination with irradiation produced synergistic delay of CT26 tumour growth. Conclusions: Our data suggest that honokiol can exert its anticancer activity as a HIF-1 alpha inhibitor by reducing HIF-1 alpha protein level and suppressing the hypoxia-related signaling pathway. The animal experiment indicates that honokiol improves the therapeutic efficacy of radiation.en_US
dc.language.isoen_USzh_TW
dc.relationInternational Journal of Radiation Biologyen_US
dc.relation.ispartofseriesInternational Journal of Radiation Biology, Volume 87, Issue 6, Page(s) 579-590.en_US
dc.relation.urihttp://dx.doi.org/10.3109/09553002.2011.568572en_US
dc.titleHonokiol inhibits hypoxia-inducible factor-1 pathwayen_US
dc.typeJournal Articlezh_TW
dc.identifier.doi10.3109/09553002.2011.568572zh_TW
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeJournal Article-
item.cerifentitytypePublications-
item.fulltextno fulltext-
item.languageiso639-1en_US-
item.grantfulltextnone-
Appears in Collections:生物醫學研究所
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