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|標題:||The associations of circulating CD4(+)CD25(high) regulatory T cells and TGF-beta with disease activity and clinical course in patients with adult-onset Still's disease||作者:||Chen, D.Y.
|關鍵字:||CD4(+)CD25(high) regulatory T cells;transforming growth factor-beta;adult-onset Still's disease;systemic lupus erythematosus;disease;activity;systemic-lupus-erythematosus;growth-factor-beta;immunological;self-tolerance;human peripheral-blood;tnf-alpha therapy;rheumatoid-arthritis;functional-characterization;foxp3 expression;activity index;population||Project:||Connective Tissue Research||期刊/報告no：:||Connective Tissue Research, Volume 51, Issue 5, Page(s) 370-377.||摘要:||
Objective. To determine circulating levels of CD4(+)CD25(high) regulatory T (Treg) cells and transforming growth factor-beta (TGF-beta) in patients with adult-onset Still's disease (AOSD) and to examine the associations with disease activity and clinical course of this disease. Methods. The frequencies of circulating CD4(+)CD25(high) Treg cells in 52 active AOSD patients, 42 active systemic lupus erythematosus (SLE) patients, and 22 healthy controls (HCs) were determined using flow cytometry analysis. Levels of serum TGF-beta and soluble interleukin-2 receptor (sIL-2R) were measured by enzyme-linked immunosorbent assay. Results. Significantly lower levels of circulating CD4(+)CD25(high) Treg cells and serum TGF-beta were found in AOSD patients and SLE patients than those found in HCs. Levels of circulating CD4(+)CD25(high) Treg cells and TGF-beta were inversely correlated with disease activity scores for AOSD patients and SLE patients. Circulating CD4(+)CD25(high) Treg cell frequencies were positively correlated with serum TGF-beta levels for patients with both diseases. Levels of circulating CD4(+)CD25(high) Treg cells and TGF-beta significantly increased, paralleling clinical remission and the decrease in levels of C-reactive protein and soluble interleukin-2 receptor after effective therapy in AOSD patients. AOSD patients with monocyclic course had significantly higher levels of circulating CD4(+)CD25(high) Treg cells and TGF-beta compared to those with polycyclic and chronic articular course. Conclusion. Diminished levels of circulating CD4(+)CD25(high) Treg cells and TGF-beta, and inverse correlation with disease activity in patients with AOSD and SLE might be involved in the pathogenesis of both diseases. Increased levels of circulating CD4(+)CD25(high) Treg cells or TGF-beta might be associated with a favorable clinical course in AOSD patients.
|Appears in Collections:||生物醫學研究所|
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