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標題: Functional Association of Interleukin 18 Gene-607 (C/A) Promoter Polymorphisms with Disease Course in Chinese Patients with Adult-onset Still's Disease
作者: Chen, D.Y.
Chen, Y.M.
Chen, H.H.
Hsieh, C.W.
Lin, C.C.
Lan, J.L.
關鍵字: interleukin 18;promoter polymorphisms;disease course;chinese;adult-onset still's disease;single-nucleotide polymorphisms;clinical-manifestations;pathological;tissues;japanese population;cytokine profiles;arthritis;complications;genotype;blood;gamma
Project: Journal of Rheumatology
期刊/報告no:: Journal of Rheumatology, Volume 36, Issue 10, Page(s) 2284-2289.
Objective. Interleukin 18 (IL-18) has a central role in the pathogenesis of adult-onset Still's disease (AOSD). We investigated the functional association of -607 (C/A) IL-I8 promoter polymorphisms with disease course in Chinese patients with AOSD. Methods. Sequence-specific primer polymerase chain reaction and the restriction fragment-length polymorphism method were used to analyze the genotypes of IL-18 promoter polymorphism at position -607 in 96 unrelated patients with AOSD and 164 ethnically-matched healthy controls. Serum IL-18 levels were determined using ELISA in patients with active untreated AOSD. Results. Significantly lower frequencies of single-nucleotide polymorphism -607/AA were observed in patients with AOSD compared to healthy controls (18.8% vs 31.1%, respectively; p < 0.05). Median levels of serum IL-18 were significantly lower in AOSD patients with AA genotype compared to those with CA genotype or CC genotype (147.5 pg/ml vs 410.5 pg/ml or 262.4 pg/ml, respectively; both p < 0.05). Significantly lower IL-18 levels were demonstrated in AOSD patients with a monocyclic systemic course than in those with a polycyclic systemic course or a chronic articular course. The AA genotype was more frequently observed in patients with monocyclic systemic course, which had the best prognosis, than in those with the other 2 disease courses. In contrast, a lower frequency of the AA genotype than the CA or the CC genotype was observed in patients with chronic disabling arthritis (5.5% vs 25.0% or 19.2%, respectively). Conclusion. The SNP -607/AA genotype with lower IL-18 levels might be a genetically protective factor for the occurrence of AOSD in the Chinese population, against progression of chronic disabling arthritis. (First Release August 15 2009: J Rheumatol 2009;36:2284-9; doi:10.3899/jrheum.090316)
ISSN: 0315-162X
DOI: 10.3899/jrheum.090316
Appears in Collections:生物醫學研究所

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