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標題: Potentiation of angiogenesis and regeneration by G-CSF after sciatic nerve crush injury
作者: Pan, H.C.
Wu, H.T.
Cheng, F.C.
Chen, C.H.
Sheu, M.L.
Chen, C.J.
關鍵字: Angiogenesis;Bone marrow;G-CSF;Hematopoietic stem cells;colony-stimulating factor;spinal-cord-injury;stem-cells;cerebral-ischemia;endothelial-cells;peripheral-blood;repair;rats;transplantation;neurogenesis
Project: Biochemical and Biophysical Research Communications
期刊/報告no:: Biochemical and Biophysical Research Communications, Volume 382, Issue 1, Page(s) 177-182.
Granulocyte Colony-Stimulating factor (G-CSF) demonstrates neuroprotective effects through different mechanisms, including mobilization of bone marrow cells. However, the influence of G-CSF-mediated mobilization of bone marrow-derived cells on injured sciatic nerves remains to be elucidated. The administration of G-CSF promoted a short-term functional recovery 7 days after crush injury in sciatic nerves. A double-immunofluorescence study using green fluorescent protein-chimeric mice revealed that bone marrow-derived CD34+ cells were predominantly mobilized and migrated into injured nerves after G-CSF treatment. G-CSF-mediated beneficial effects against sciatic nerve injury were associated with increased CD34+ cell deposition, vascular endothelial growth factor (VEGF) expression, and vascularization/angiogenesis as well as decreased CD68+ cell accumulation. However, cell differentiation and VEGF expression were not demonstrated in deposited cells. The results suggest that the promotion of short-term functional recovery in sciatic nerve crush injury by G-CSF involves a paracrine modulatory effect and a bone marrow-derived CD34+ cell mobilizing effect. (C) 2009 Elsevier Inc. All rights reserved.
ISSN: 0006-291X
DOI: 10.1016/j.bbrc.2009.03.003
Appears in Collections:生物醫學研究所

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