Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/40328
DC FieldValueLanguage
dc.contributor.authorChang, T.P.en_US
dc.contributor.author陳健尉zh_TW
dc.contributor.authorYu, S.L.en_US
dc.contributor.authorLin, S.Y.en_US
dc.contributor.authorHsiao, Y.J.en_US
dc.contributor.authorChang, G.C.en_US
dc.contributor.authorYang, P.C.en_US
dc.contributor.authorChen, J.J.W.en_US
dc.date2010zh_TW
dc.date.accessioned2014-06-06T08:03:36Z-
dc.date.available2014-06-06T08:03:36Z-
dc.identifier.issn0008-5472zh_TW
dc.identifier.urihttp://hdl.handle.net/11455/40328-
dc.description.abstractHLJ1, a member of the heat shock protein 40 chaperone family, is a newly identified tumor suppressor that has been implicated in tumorigenesis and metastasis in non-small cell lung cancer. However, the mechanism of HLJ1 action is presently obscure. In this study, we report that HLJ1 specifically interacts with the nuclear protein nucleophosmin (NPM1), forming a multiprotein complex that alters the nucleolar distribution and oligomerization state of NPM1. Enforced accumulation of NPM1 oligomers by overexpression in weakly invasive but high HLJ1-expressing cells induced the activity of signal transducer and activator of transcription 3 (STAT3) and increased cellular migration, invasiveness, and colony formation. Furthermore, silencing HLJ1 accelerated NPM1 oligomerization, inhibited the activity of transcription corepressor activating enhancer binding protein 2 alpha (AP-2 alpha), and increased the activities of matrix metalloproteinase-2 (MMP-2) and STAT3. Our findings suggest that HLJ1 switches the role of NPM1, which can act as tumor suppressor or oncogene, by modulating the oligomerization of NPM1 via HLJ1-NPM1 heterodimer formation and recruiting AP-2 alpha to the MMP-2 promoter. Cancer Res; 70(4); 1656-67. (C) 2010 AACR.en_US
dc.language.isoen_USzh_TW
dc.relationCancer Researchen_US
dc.relation.ispartofseriesCancer Research, Volume 70, Issue 4, Page(s) 1656-1667.en_US
dc.relation.urihttp://dx.doi.org/10.1158/0008-5472.can-09-2453en_US
dc.subjectnucleolar phosphoprotein b23en_US
dc.subjectheat-shock-proteinen_US
dc.subjectcell lung-canceren_US
dc.subjecttranscription factorsen_US
dc.subjectovarian-canceren_US
dc.subjectbreast-canceren_US
dc.subjectup-regulationen_US
dc.subjectinvasionen_US
dc.subjectapoptosisen_US
dc.subjectgrowthen_US
dc.titleTumor Suppressor HLJ1 Binds and Functionally Alters Nucleophosmin via Activating Enhancer Binding Protein 2 alpha Complex Formationen_US
dc.typeJournal Articlezh_TW
dc.identifier.doi10.1158/0008-5472.can-09-2453zh_TW
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.languageiso639-1en_US-
item.openairetypeJournal Article-
item.grantfulltextnone-
item.fulltextno fulltext-
item.cerifentitytypePublications-
Appears in Collections:生物醫學研究所
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