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標題: Unique microRNA signature and clinical outcome of cancers
作者: Yu, S.L.
Chen, H.Y.
Yang, P.C.
Chen, J.J.W.
關鍵字: angiotensin-ii type-1;cell lung-cancer;chronic lymphocytic-leukemia;down-regulation;breast-cancer;c-myc;expression;gene;rna;targets
Project: DNA and Cell Biology
期刊/報告no:: DNA and Cell Biology, Volume 26, Issue 5, Page(s) 283-292.
MicroRNAs (miRNAs) are endogenous small non-protein-coding RNAs (18-25 nucleotides) that conduct the post-transcriptional repression of hundreds of their target proteins. They regulate many kinds of basic cellular processes including proliferation, differentiation, stress response, and cell death. Recent evidence has shown that deregulation of miRNAs correlates with certain features of diverse cancers ( such as tumorigenesis, differentiation status, and outcome of tumor patients), and indicates that miRNAs can act as oncogenes or tumor suppressors. Here, we summarize these recent studies and provide a new perspective on understanding the role of miRNAs in initiation and progression of cancers. We also discuss the future applications of miRNAs in diagnostic and prognostic implications of cancers.
ISSN: 1044-5498
DOI: 10.1089/dna.2006.0555
Appears in Collections:生物醫學研究所

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