Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/40341
DC FieldValueLanguage
dc.contributor.authorWang, C.C.en_US
dc.contributor.author陳健尉zh_TW
dc.contributor.authorChen, J.J.W.en_US
dc.contributor.authorYang, P.C.en_US
dc.date2006zh_TW
dc.date.accessioned2014-06-06T08:03:37Z-
dc.date.available2014-06-06T08:03:37Z-
dc.identifier.issn1472-8222zh_TW
dc.identifier.urihttp://hdl.handle.net/11455/40341-
dc.description.abstractThe multifunctional transcription factor Yin Yang 1 (YY1) is a complex protein that has been shown to play pivotal roles in development, differentiation, cellular proliferation and apoptosis. It can act as a transcriptional repressor, an activator, or an initiator element binding protein that directs and initiates transcription of numerous cellular and viral genes. Because the expression and function of YY1 are known to be intimately associated with cell-cycle progression, the physiological significance of YY1 activity has recently been applied to models of cancer biology. Several lines of evidence imply that YY1 expression and/or activation is associated with tumourigenesis, in addition to its regulatory roles in normal biological processes. However, controversial results also raised and indicated that further studies are still needed to piece all of the seemingly contradictory data into a complete picture. On the basis of YY1 regulations and functions, novel drugs and specific treatment strategies may be developed with new therapeutic applications for tumour patients in the future.en_US
dc.language.isoen_USzh_TW
dc.relationExpert Opinion on Therapeutic Targetsen_US
dc.relation.ispartofseriesExpert Opinion on Therapeutic Targets, Volume 10, Issue 2, Page(s) 253-266.en_US
dc.relation.urihttp://dx.doi.org/10.1517/14728222.10.2.253en_US
dc.subjectapoptosisen_US
dc.subjectcell invasionen_US
dc.subjectdifferentiationen_US
dc.subjectHLJ1en_US
dc.subjecttranscriptionalen_US
dc.subjectregulationen_US
dc.subjectYY1en_US
dc.subjectnf-kappa-ben_US
dc.subjectepstein-barr-virusen_US
dc.subjectserum response factoren_US
dc.subjectyin-yang 1en_US
dc.subjectnuclear differentiation antigenen_US
dc.subjectpapillomavirus type-18 promoteren_US
dc.subjectmediated cell-adhesionen_US
dc.subjectmurine leukemia-virusen_US
dc.subjectalpha-actin promoteren_US
dc.subjectzinc-finger proteinen_US
dc.titleMultifunctional transcription factor YY1: a therapeutic target in human cancer?en_US
dc.typeJournal Articlezh_TW
dc.identifier.doi10.1517/14728222.10.2.253zh_TW
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.languageiso639-1en_US-
item.openairetypeJournal Article-
item.grantfulltextnone-
item.fulltextno fulltext-
item.cerifentitytypePublications-
Appears in Collections:生物醫學研究所
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