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標題: Titanium dioxide nanoparticles induce emphysema-like lung injury in mice
作者: Chen, H.W.
Su, S.F.
Chien, C.T.
Lin, W.H.
Yu, S.L.
Chou, C.C.
Chen, J.J.W.
Yang, P.C.
關鍵字: nanotechnology;chemokines;placenta growth factor;microarray;pulmonary emphysema;placental growth-factor;obstructive pulmonary-disease;epithelial-cells;gene-expression;intratracheal instillation;alveolar;macrophages;in-vitro;rat lung;particles;inflammation
Project: Faseb Journal
期刊/報告no:: Faseb Journal, Volume 20, Issue 13, Page(s) 2393-+.
Titanium dioxide nanoparticles (nanoTiO(2)) have been widely used as a photocatalyst in air and water cleaning. However, these nanoparticles inhalation can induce pulmonary toxicity and its mechanism is not fully understood. In this study we investigated the pulmonary toxicity of nanoTiO(2) and its molecular pathogenesis. The adult male ICR mice were exposed to intratracheal single dose of 0.1 or 0.5 mg nanoTiO(2) (19 - 21 nm) and lung tissues were collected at 3rd day, 1st wk, and 2nd wk for morphometric, microarray gene expression, and pathway analyses. NanoTiO(2) can induce pulmonary emphysema, macrophages accumulation, extensive disruption of alveolar septa, type II pneumocyte hyperplasia, and epithelial cell apoptosis. NanoTiO2 induced differential expression of hundreds of genes include activation of pathways involved in cell cycle, apoptosis, chemokines, and complement cascades. In particular, nanoTiO(2) up-regulates placenta growth factor ( PlGF) and other chemokines (CXCL1, CXCL5, and CCL3) expressions that may cause pulmonary emphysema and alveolar epithelial cell apoptosis. Cultured human THP-1 cell-derived macrophages treated with nanoTiO2 in vitro also resulted in upregulations of PlGF, CXCL1, CXCL5, and CCL3. These results indicated that nanoTiO2 can induce severe pulmonary emphysema, which may be caused by activation of PlGF and related inflammatory pathways.
ISSN: 0892-6638
DOI: 10.1096/fj.06-6485fje
Appears in Collections:生物醫學研究所

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