Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/40344
DC FieldValueLanguage
dc.contributor.authorChen, H.W.en_US
dc.contributor.author陳健尉zh_TW
dc.contributor.authorSu, S.F.en_US
dc.contributor.authorChien, C.T.en_US
dc.contributor.authorLin, W.H.en_US
dc.contributor.authorYu, S.L.en_US
dc.contributor.authorChou, C.C.en_US
dc.contributor.authorChen, J.J.W.en_US
dc.contributor.authorYang, P.C.en_US
dc.date2006zh_TW
dc.date.accessioned2014-06-06T08:03:38Z-
dc.date.available2014-06-06T08:03:38Z-
dc.identifier.issn0892-6638zh_TW
dc.identifier.urihttp://hdl.handle.net/11455/40344-
dc.description.abstractTitanium dioxide nanoparticles (nanoTiO(2)) have been widely used as a photocatalyst in air and water cleaning. However, these nanoparticles inhalation can induce pulmonary toxicity and its mechanism is not fully understood. In this study we investigated the pulmonary toxicity of nanoTiO(2) and its molecular pathogenesis. The adult male ICR mice were exposed to intratracheal single dose of 0.1 or 0.5 mg nanoTiO(2) (19 - 21 nm) and lung tissues were collected at 3rd day, 1st wk, and 2nd wk for morphometric, microarray gene expression, and pathway analyses. NanoTiO(2) can induce pulmonary emphysema, macrophages accumulation, extensive disruption of alveolar septa, type II pneumocyte hyperplasia, and epithelial cell apoptosis. NanoTiO2 induced differential expression of hundreds of genes include activation of pathways involved in cell cycle, apoptosis, chemokines, and complement cascades. In particular, nanoTiO(2) up-regulates placenta growth factor ( PlGF) and other chemokines (CXCL1, CXCL5, and CCL3) expressions that may cause pulmonary emphysema and alveolar epithelial cell apoptosis. Cultured human THP-1 cell-derived macrophages treated with nanoTiO2 in vitro also resulted in upregulations of PlGF, CXCL1, CXCL5, and CCL3. These results indicated that nanoTiO2 can induce severe pulmonary emphysema, which may be caused by activation of PlGF and related inflammatory pathways.en_US
dc.language.isoen_USzh_TW
dc.relationFaseb Journalen_US
dc.relation.ispartofseriesFaseb Journal, Volume 20, Issue 13, Page(s) 2393-+.en_US
dc.relation.urihttp://dx.doi.org/10.1096/fj.06-6485fjeen_US
dc.subjectnanotechnologyen_US
dc.subjectchemokinesen_US
dc.subjectplacenta growth factoren_US
dc.subjectmicroarrayen_US
dc.subjectpulmonary emphysemaen_US
dc.subjectplacental growth-factoren_US
dc.subjectobstructive pulmonary-diseaseen_US
dc.subjectepithelial-cellsen_US
dc.subjectgene-expressionen_US
dc.subjectintratracheal instillationen_US
dc.subjectalveolaren_US
dc.subjectmacrophagesen_US
dc.subjectin-vitroen_US
dc.subjectrat lungen_US
dc.subjectparticlesen_US
dc.subjectinflammationen_US
dc.titleTitanium dioxide nanoparticles induce emphysema-like lung injury in miceen_US
dc.typeJournal Articlezh_TW
dc.identifier.doi10.1096/fj.06-6485fjezh_TW
item.cerifentitytypePublications-
item.grantfulltextnone-
item.languageiso639-1en_US-
item.fulltextno fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeJournal Article-
Appears in Collections:生物醫學研究所
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