Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/40350
DC FieldValueLanguage
dc.contributor.authorYuan, A.en_US
dc.contributor.author陳健尉zh_TW
dc.contributor.authorChen, J.J.W.en_US
dc.contributor.authorYao, P.L.en_US
dc.contributor.authorYang, P.C.en_US
dc.date2005zh_TW
dc.date.accessioned2014-06-06T08:03:38Z-
dc.date.available2014-06-06T08:03:38Z-
dc.identifier.issn1093-9946zh_TW
dc.identifier.urihttp://hdl.handle.net/11455/40350-
dc.description.abstractInterleukin (IL)-8, a cytokine of the CXC chemokine family that was originally classified as a neutrophil chemoattractant, is now reported to play an important role in tumor progression and metastasis in a variety of human cancers, including lung cancers. IL-8 biologic activity in tumors and the tumor microenvironment may contribute to tumor progression through its potential function in the regulation of angiogenesis, cancer cell growth and survival, tumor cell motion, leukocyte infiltration and modification of immune responses. Recently, infiltrating macrophages in tumor stroma have been considered to be able to stimulate cancer growth, enhance angiogenesis and promote metastasis, and has prognostic significance in several human cancers. Accumulating evidence also shows that cancer cells and stromal cell interaction can stimulate cancer cells, as well as stromal cells in the expression of IL-8 and other growth factors. Here, we summarize current information about IL-8 biology in human lung cancers and focus on its effect on tumor angiogenesis, regulation of IL-8 expression in tumors, its prognostic significances, the role of tumor infiltrating macrophages in the production of IL-8 in cancer cells and the tumor microenvironment, gene expression profiles after cancer cell-stromal cell interaction, and the effect of a variety anti-inflammatory drugs on the modification of IL-8 and other gene expressions in cancer cells and the tumor microenvironment in lung cancers.en_US
dc.language.isoen_USzh_TW
dc.relationFrontiers in Bioscienceen_US
dc.relation.ispartofseriesFrontiers in Bioscience, Volume 10, Page(s) 853-865.en_US
dc.relation.urihttp://dx.doi.org/10.2741/1579en_US
dc.subjectIL-8en_US
dc.subjectcancer cellsen_US
dc.subjectmicroenvironmenten_US
dc.subjectstroma cellen_US
dc.subjecttumor infiltratingen_US
dc.subjectmacrophageen_US
dc.subjectangiogenesisen_US
dc.subjectgene expressions profileen_US
dc.subjectinteractionen_US
dc.subjectreviewen_US
dc.subjecthuman-melanoma cellsen_US
dc.subjectendothelial growth-factoren_US
dc.subjecttumor-necrosis-factoren_US
dc.subjecthuman-malignant melanomaen_US
dc.subjectleukocyte chemotactic cytokinesen_US
dc.subjectfocalen_US
dc.subjectmacrophage infiltrationen_US
dc.subjectprimary cutaneous melanomaen_US
dc.subjectmessenger-rnaen_US
dc.subjectexpressionen_US
dc.subjectactivating factor mcafen_US
dc.subjecttrans-retinoic aciden_US
dc.titleThe role of interleukin-8 in cancer cells and microenvironment interactionen_US
dc.typeJournal Articlezh_TW
dc.identifier.doi10.2741/1579zh_TW
item.cerifentitytypePublications-
item.grantfulltextnone-
item.languageiso639-1en_US-
item.fulltextno fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeJournal Article-
Appears in Collections:生物醫學研究所
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