Please use this identifier to cite or link to this item:
標題: MicroRNA signature predicts survival and relapse in lung cancer
作者: Yu, S.L.
Chen, H.Y.
Chang, G.C.
Chen, C.Y.
Chen, H.W.
Singh, S.
Cheng, C.L.
Yu, C.J.
Lee, Y.C.
Chen, H.S.
Su, T.J.
Chiang, C.C.
Li, H.N.
Hong, Q.S.
Su, H.Y.
Chen, C.C.
Chen, W.J.
Liu, C.C.
Chan, W.K.
Li, K.C.
Chen, J.J.W.
Yang, P.C.
關鍵字: gene-expression;adjuvant chemotherapy;cell lines;let-7;prognosis;adenocarcinoma;tumors;oncogenes;targets;model
Project: Cancer Cell
期刊/報告no:: Cancer Cell, Volume 13, Issue 1, Page(s) 48-57.
We investigated whether microRNA expression profiles can predict clinical outcome of NSCLC patients. Using real-time RT-PCR, we obtained microRNA expressions in 112 NSCLC patients, which were divided into the training and testing sets. Using Cox regression and risk-score analysis, we identified a five-microRNA signature for the prediction of treatment outcome of NSCLC in the training set. This microRNA signature was validated by the testing set and an independent cohort. Patients with high-risk scores in their microRNA signatures had poor overall and disease-free survivals compared to the low-risk-score patients. This microRNA signature is an independent predictor of the cancer relapse and survival of NSCLC patients.
ISSN: 1535-6108
DOI: 10.1016/j.ccr.2007.12.008
Appears in Collections:生物醫學研究所

Show full item record

Google ScholarTM




Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.