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|標題:||MicroRNA signature predicts survival and relapse in lung cancer||作者:||Yu, S.L.
|關鍵字:||gene-expression;adjuvant chemotherapy;cell lines;let-7;prognosis;adenocarcinoma;tumors;oncogenes;targets;model||Project:||Cancer Cell||期刊/報告no：:||Cancer Cell, Volume 13, Issue 1, Page(s) 48-57.||摘要:||
We investigated whether microRNA expression profiles can predict clinical outcome of NSCLC patients. Using real-time RT-PCR, we obtained microRNA expressions in 112 NSCLC patients, which were divided into the training and testing sets. Using Cox regression and risk-score analysis, we identified a five-microRNA signature for the prediction of treatment outcome of NSCLC in the training set. This microRNA signature was validated by the testing set and an independent cohort. Patients with high-risk scores in their microRNA signatures had poor overall and disease-free survivals compared to the low-risk-score patients. This microRNA signature is an independent predictor of the cancer relapse and survival of NSCLC patients.
|Appears in Collections:||生物醫學研究所|
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