Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/40429
DC FieldValueLanguage
dc.contributor.authorLiu, C.C.en_US
dc.contributor.author陳健尉zh_TW
dc.contributor.authorLin, C.C.en_US
dc.contributor.authorChen, W.S.E.en_US
dc.contributor.authorChen, H.Y.en_US
dc.contributor.authorChang, P.C.en_US
dc.contributor.authorChen, J.J.W.en_US
dc.contributor.authorYang, P.C.en_US
dc.contributor.author劉俊吉zh_TW
dc.date2006zh_TW
dc.date.accessioned2014-06-06T08:03:45Z-
dc.date.available2014-06-06T08:03:45Z-
dc.identifier.issn0305-1048zh_TW
dc.identifier.urihttp://hdl.handle.net/11455/40429-
dc.description.abstractTranscription factors (TFs) and microRNAs play important roles in the regulation of human gene expression, and the study of their combinatory regulations of gene expression is a new research field. We constructed a comprehensive web server, the composite regulatory signature database (CRSD), that can be applied in investigating complex regulatory behaviors involving gene expression signatures (GESs), microRNA regulatory signatures (MRSs) and TF regulatory signatures (TRSs). Six well-known and large-scale databases, including the human UniGene, mature microRNAs, putative promoter, TRANSFAC, pathway and Gene Ontology (GO) databases, were integrated to provide the comprehensive analysis in CRSD. Two new genome-wide databases, of MRSs and TRSs, were also constructed and further integrated into CRSD. To accomplish the microarray data analysis at one go, several methods, including microarray data pretreatment, statistical and clustering analysis, iterative enrichment analysis and motif discovery, were closely integrated in the web server, which has not been the case in previous studies. Our implementation showed that the published literature could demonstrate the results of genome-wide enrichment analysis. We conclude that CRSD is a powerful and useful bioinformatic web server and may provide new insights into gene regulation networks. CRSD and the online tutorial are publicly available at http://biochip.nchu.edu.tw/crsd1/.en_US
dc.language.isoen_USzh_TW
dc.relationNucleic Acids Researchen_US
dc.relation.ispartofseriesNucleic Acids Research, Volume 34, Page(s) W571-W577.en_US
dc.relation.urihttp://dx.doi.org/10.1093/nar/gkl279en_US
dc.subjectfactor-binding sitesen_US
dc.subjecttranscriptional regulationen_US
dc.subjectcancer transcriptomeen_US
dc.subjectc-mycen_US
dc.subjectgeneen_US
dc.subjectexpressionen_US
dc.subjectidentificationen_US
dc.subjectmicrornasen_US
dc.subjectdifferentiationen_US
dc.subjectsequencesen_US
dc.titleCRSD: a comprehensive web server for composite regulatory signature discoveryen_US
dc.typeJournal Articlezh_TW
dc.identifier.doi10.1093/nar/gkl279zh_TW
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextno fulltext-
item.cerifentitytypePublications-
item.grantfulltextnone-
item.languageiso639-1en_US-
item.openairetypeJournal Article-
Appears in Collections:生物醫學研究所
Show simple item record
 

Google ScholarTM

Check

Altmetric

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.