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標題: Bioactive Phytochemicals of Leaf Essential Oils of Cinnamomum osmophloeum Prevent Lipopolysaccharide/D-Galactosamine (LPS/D-GalN)-Induced Acute Hepatitis in Mice
作者: Tung, Y.T.
Huang, C.C.
Ho, S.T.
Kuo, Y.H.
Lin, C.C.
Lin, C.T.
Wu, J.H.
關鍵字: Cinnamomum osmophloeum;essential oil;hepatoprotection;lipopolysaccharide/D-galactosamine (LPS/D-GalN);acute liver failure;(ALF);tumor-necrosis-factor;acute liver-failure;down-regulation;tnf-alpha;injury;macrophages;phytocompounds;suppression;expression;growth
Project: Journal of Agricultural and Food Chemistry
期刊/報告no:: Journal of Agricultural and Food Chemistry, Volume 59, Issue 15, Page(s) 8117-8123.
The purpose of this study was to investigate the bioactive phytochemicals of leaf essential oils of Cinnamomum osmophloeum on lipopolysaccharide/D-galactosamine (LPS/D-GalN)-induced acute hepatitis. The results revealed that post-treatment with 100 mu mol/kg trans-cinnamaldehyde, (-)-aromadendrene, T-cadinol, or alpha-cadinol significantly decreased the aspartate aminotransferase (AST), alanine aminotransferase (ALT), tumor necrosis factor-alpha (TNF-alpha), and interleukin 6 (IL-6) levels in serum. Moreover, both T-cadinol and alpha-cadinol treatments decreased the expressions of cleaved caspase-3 and cleaved poly-ADP ribose polymerase (PARP) in the liver tissues when compared with the LPS/D-GalN group. Liver histopathology also showed that silymarin, trans-cinnamaldehyde, (-)-aromadendrene, T-cadinol, or alpha-cadinol significantly reduced the incidence of liver lesions induced by LPS/D-GalN. These results suggest that the above phytochemicals exhibit potent hepatoprotection against LPS/D-GalN-induced liver damage in mice, and their hepatoprotective effects may be due to the modulation of anti-inflammatory activities.
ISSN: 0021-8561
DOI: 10.1021/jf2018935
Appears in Collections:生物醫學研究所

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