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標題: Infection of human papillomavirus and overexpression of dihydrodiol dehydrogenase in uterine cervical cancer
作者: Ueda, M.
Hung, Y.C.
Chen, J.T.
Chiou, S.H.
Huang, H.H.
Lin, T.Y.
Terai, Y.
Chow, K.C.
關鍵字: HPV;DDH;uterine cervical cancer;survival;drug resistance;carcinoma cell-lines;intraepithelial neoplasia;human liver;in-vitro;interleukin-6;expression;dna;resistance;proliferation;purification
Project: Gynecologic Oncology
期刊/報告no:: Gynecologic Oncology, Volume 102, Issue 2, Page(s) 173-181.
Objective. To determine the association of human papillomavirus (HPV) infection with the expression of dihydrodiol dehydrogenase (DDH) in uterine cervical cancer (UCC). Methods. In situ hybridization (ISH) and immunohistochemistry were applied to examine pathological specimens of 145 patients with UCC. Results. By ISH, HPV16/18 DNA was detected in 108 (74.5%) UCC cases. DDH expression determined by immunohistochemistry was detected in 81 (75%) lesions among 108 HPV-positive cases. In contrast, of 37 HPV-negative cases, DDH was only detected in 16 (43.2%) of the lesions. A significant correlation was found between DDH expression and the presence of HPV (P < 0.001), FIGO stage (P = 0.004), lymph node involvement (P < 0.001), as well as patients' survival (P = 0.002). In vitro, DDH expression was also found closely associated with HPV infection, and DDH content was proportional to cell sensitivity for cisplatin and doxorubicin. Conclusions. HPV infection provokes local inflammation, which can then induce DDH expression and drug resistance in UCC. The detailed biological relationship among HPV infection, expression of DDH and drug resistance, however, remains to be clarified. (c) 2005 Elsevier Inc. All rights reserved.
ISSN: 0090-8258
DOI: 10.1016/j.ygyno.2005.12.009
Appears in Collections:生物醫學研究所

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